Guidi Sofia, Berghella Vincenzo, Scambia Giovanni, Fagotti Anna, Vidiri Annalisa, Restaino Stefano, Vizzielli Giuseppe, Inzani Frediano, Cavaliere Anna Franca
Department of Obstetrics and Gynecology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Healthcare (Basel). 2021 Oct 27;9(11):1455. doi: 10.3390/healthcare9111455.
Granulosa cell tumors are rare ovarian tumors that can arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic review of the literature. The new case described is a 41-year-old woman G5P1122 with a prior history of AGCT that was referred to our center at 29 weeks because of a symptomatic abdominal mass, compatible with a possible recurrence of AGCT. At 36 + 3 weeks, she underwent a cesarean delivery for preterm labor and a total hysterectomy with a radical surgical staging. A healthy female infant was delivered. The patient received a platinum-based chemotherapy, with a 26-month follow-up negative for recurrence. Analyzing our case with the four identified by the literature review, three were recurrent and two were primary AGCT. Only one required surgery for AGCT at 15 weeks, while another underwent chemotherapy in pregnancy. In the other three cases, surgery for AGCT was done at the time of cesarean delivery. There were three cases of preterm delivery. All five pregnancies resulted in the birth of live babies with weight adequate for gestational age. In conclusion, AGCT diagnosed in pregnancy is rare, reported in only five cases. All gave birth to live babies in the third trimester, and maternal outcome at up to 18 months showed no recurrence.
颗粒细胞瘤是一种罕见的卵巢肿瘤，可在孕期发生。我们报告一例孕期复发性成人颗粒细胞瘤（AGCT）的新病例，并对相关文献进行系统综述。所描述的新病例是一名41岁、孕5产1122的女性，既往有AGCT病史，因出现有症状的腹部肿块于孕29周转诊至我院，该肿块可能提示AGCT复发。孕36 + 3周时，因早产行剖宫产，并进行了根治性手术分期的全子宫切除术。产下一名健康女婴。患者接受了铂类化疗，随访26个月无复发。将我们的病例与文献综述中确定的4例病例进行分析，其中3例为复发性，2例为原发性AGCT。仅1例在孕15周时因AGCT接受手术，另1例在孕期接受化疗。其他3例在剖宫产时行AGCT手术。有3例早产。所有5次妊娠均分娩出适于胎龄的活婴。总之，孕期诊断的AGCT很罕见，仅报告了5例。所有病例均在孕晚期分娩出活婴，且至18个月时产妇预后无复发。
