Ríos-Tamayo Rafael, Puig Noemí, Algarín Macarena, García de Veas Silva José Luís, Barbosa Nuno, Encinas Cristina, Hernández José Ángel, Alonso Rafael, Campos María Luisa, Rodríguez Teresa, Leivas Alberto, Olivares María José, Sánchez María José, Paiva Bruno, Lahuerta Juan José, Martínez-López Joaquín
Hematology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), 18014 Granada, Spain.
Diagnostics (Basel). 2021 Oct 30;11(11):2020. doi: 10.3390/diagnostics11112020.
Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients. The diagnosis, prognosis, clinical monitoring and evaluation of the response are key moments in the clinical care process. Conventional laboratory methods have been and continue to be the basis of laboratory testing in monoclonal gammopathies, along with the serum free light chain test. However, more accurate methods are needed to achieve new and more stringent clinical goals. The heavy/light chain assay is a relatively new test which can overcome some of the limitations of the conventional methods for the evaluation of intact immunoglobulin MM patients. Here, we report an update of the evidence accumulated in recent years on this method regarding its use in MM.
尽管近年来取得了巨大进展，但多发性骨髓瘤（MM）仍然是一种具有挑战性的疾病。实验室在患者的整体管理中起着关键作用。诊断、预后、临床监测以及反应评估是临床护理过程中的关键环节。传统实验室方法一直是单克隆丙种球蛋白病实验室检测的基础，血清游离轻链检测也是如此。然而，需要更准确的方法来实现新的、更严格的临床目标。重链/轻链分析是一种相对较新的检测方法，它可以克服传统方法在评估完整免疫球蛋白MM患者时的一些局限性。在此，我们报告近年来积累的关于该方法在MM中应用的证据更新情况。
