Moniaga Catharina Sagita, Tominaga Mitsutoshi, Takamori Kenji
Juntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Graduate School of Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan.
Anti-Aging Skin Research Laboratory, Graduate School of Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan.
Diagnostics (Basel). 2021 Nov 12;11(11):2090. doi: 10.3390/diagnostics11112090.
Accumulated evidence on type 2 inflammation-associated itch in atopic dermatitis has recently been reported. Crosstalk between the immune and nervous systems (neuroimmune interactions) is prominent in atopic dermatitis research, particularly regarding itch and inflammation. A comprehensive understanding of bidirectional neuroimmune interactions will provide insights into the pathogenesis of itch and its treatment. There is currently no agreed cure for itch in atopic dermatitis; however, increasing numbers of novel and targeted biologic agents have potential for its management and are in the advanced stages of clinical trials. In this review, we summarize and discuss advances in our understanding of type 2 inflammation-associated itch and implications for its management and treatment in patients with atopic dermatitis.
最近有报道称，关于特应性皮炎中2型炎症相关瘙痒的证据不断积累。免疫和神经系统之间的相互作用（神经免疫相互作用）在特应性皮炎研究中十分突出，尤其是在瘙痒和炎症方面。全面了解双向神经免疫相互作用将有助于深入了解瘙痒的发病机制及其治疗方法。目前，特应性皮炎中的瘙痒尚无公认的治愈方法；然而，越来越多新型且有针对性的生物制剂有治疗潜力，并且正处于临床试验的后期阶段。在本综述中，我们总结并讨论了对2型炎症相关瘙痒的认识进展，以及其对特应性皮炎患者管理和治疗的意义。
