Constantin Adrian, Achim Florin, Spinu Dan, Socea Bogdan, Predescu Dragos
General and Esophageal Clinic, Sf. Maria Clinical Hospital Bucharest, Carol Davila University of Medicine and Pharmacy, 011172 Bucharest, Romania.
Department of Urology, Central Military Emergency University Hospital Bucharest, Carol Davila University of Medicine and Pharmacy, 010825 Bucharest, Romania.
Diagnostics (Basel). 2021 Nov 15;11(11):2112. doi: 10.3390/diagnostics11112112.
Idiopathic megacolon (IM) is a rare condition with a more or less known etiology, which involves management challenges, especially therapeutic, and both gastroenterology and surgery services. With insufficiently drawn out protocols, but with occasionally formidable complications, the condition management can be difficult for any general surgery team, either as a failure of drug therapy (in the context of a known case, initially managed by a gastroenterologist) or as a surgical emergency (in which the diagnostic surprise leads additional difficulties to the tactical decision), when the speed imposed by the severity of the case can lead to inadequate strategies, with possibly critical consequences.
With such a motivation, and having available experience limited by the small number of cases (described by all medical teams concerned with this pathology), the revision of the literature with the update of management landmarks from the surgical perspective of the pathology appears as justified by this article.
If the diagnosis of megacolon is made relatively easily by imaging the colorectal dilation (which is associated with initial and/or consecutive clinical aspects), the establishing of the diagnosis of idiopathic megacolon is based in practice almost exclusively on a principle of exclusion, and after evaluating the absence of some known causes that can lead to the occurrence of these anatomic and clinical changes, mimetically, clinically, and paraclinically, with IM (intramural aganglionosis, distal obstructions, intoxications, etc.). If the etiopathogenic theories, based on an increase in the performance of the arsenal of investigations of the disease, have registered a continuous improvement and an increase of objectivity, unfortunately, the curative surgical treatment options still revolve around the same resection techniques. Moreover, the possibility of developing a form of etiopathogenic treatment seems as remote as ever.
特发性巨结肠(IM)是一种病因或多或少已知的罕见病症,它带来了管理挑战,尤其是治疗方面的挑战,涉及胃肠病学和外科服务。由于方案不够完善,且偶尔会出现严重并发症,对于任何普通外科团队来说,这种病症的管理都可能很困难,无论是药物治疗失败(在已知病例中,最初由胃肠病学家管理)还是作为外科急症(诊断意外给战术决策带来额外困难),当病例的严重程度所带来的紧迫性可能导致策略不充分,从而可能产生严重后果时。
出于这样的动机,且由于相关病例数量少,所有关注这种病症的医疗团队的经验都有限,从该病症的外科角度对文献进行修订并更新管理里程碑似乎是合理的,本文即为此进行阐述。
如果通过对结直肠扩张进行成像(这与初始和/或后续临床症状相关)相对容易地做出巨结肠的诊断,那么特发性巨结肠的诊断实际上几乎完全基于排除原则,即在评估不存在一些已知可导致这些解剖和临床变化的原因之后,这些原因在影像学、临床和辅助检查方面与特发性巨结肠(肠壁神经节缺失、远端梗阻、中毒等)相似。如果基于对该疾病检查手段的不断改进,病因学理论在持续完善且客观性不断提高,不幸的是,根治性手术治疗方案仍然围绕着相同的切除技术。此外,开发一种病因治疗形式的可能性似乎一如既往地遥远。