Huang Jiashu, Yu Shenghao, Ding Lei, Ma Lingyuan, Chen Hongjian, Zhou Hui, Zou Yayan, Yu Min, Lin Jie, Cui Qinghua
Lab of Biochemistry & Molecular Biology, School of Life Sciences, Yunnan University, Kunming 650091, China.
Key Lab of Molecular Cancer Biology, Yunnan Education Department, Kunming 650091, China.
Biomedicines. 2021 Oct 31;9(11):1590. doi: 10.3390/biomedicines9111590.
Breast cancer (BC) and colon cancer (CRC) are the two most deadly cancers in the world. These cancers partly share the same genetic background and are partially regulated by the same genes. The outcomes of traditional chemoradiotherapy and surgery remain suboptimal, with high postoperative recurrence and a low survival rate. It is, therefore, urgent to innovate and improve the existing treatment measures. Many studies primarily reported that the microRNA (miRNA) sponge functions of circular RNA (circRNA) in BC and CRC have an indirect relationship between the circRNA-miRNA axis and malignant behaviors. With a covalent ring structure, circRNAs can regulate the expression of target genes in multiple ways, especially by acting as miRNA sponges. Therefore, this review mainly focuses on the roles of circRNAs as miRNA sponges in BC and CRC based on studies over the last three years, thus providing a theoretical reference for finding new therapeutic targets in the future.
乳腺癌（BC）和结肠癌（CRC）是世界上最致命的两种癌症。这些癌症部分具有相同的遗传背景，且部分受相同基因调控。传统放化疗和手术的效果仍不尽人意，术后复发率高且生存率低。因此，创新和改进现有治疗措施迫在眉睫。许多研究主要报道了环状RNA（circRNA）在BC和CRC中的微小RNA（miRNA）海绵功能，circRNA-miRNA轴与恶性行为之间存在间接关系。由于具有共价环状结构，circRNA可以通过多种方式调节靶基因的表达，尤其是作为miRNA海绵发挥作用。因此，本综述主要基于过去三年的研究，聚焦于circRNA作为miRNA海绵在BC和CRC中的作用，从而为未来寻找新的治疗靶点提供理论参考。
