Chillon Thilo Samson, Demircan Kamil, Heller Raban Arved, Hirschbil-Bremer Ines Maria, Diegmann Joachim, Bachmann Manuel, Moghaddam Arash, Schomburg Lutz
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, Germany.
Berlin Institute of Health (BIH), Biomedical Innovation Academy (BIA), D-10117 Berlin, Germany.
Biomedicines. 2021 Nov 18;9(11):1714. doi: 10.3390/biomedicines9111714.
The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.
对SARS-CoV-2疫苗接种的免疫反应因人而异。除年龄外，有证据表明某些微量营养素会影响免疫系统，尤其是维生素D。在此，我们分析了一组健康德国成年人从接种疫苗起24周内的SARS-CoV-2 IgG和中和效力以及25-羟基胆钙化醇[25(OH)D]浓度。与我们的预期相反，未发现SARS-CoV-2 IgG随25(OH)D状态的动态增减存在显著差异。此外，对首次或第二次接种的反应、达到的最大SARS-CoV-2 IgG浓度以及SARS-CoV-2 IgG浓度随时间的下降与25(OH)D状态无关。我们得出结论，以SARS-CoV-2 IgG浓度衡量的疫苗接种反应并不取决于维生素D状态中等的健康成年人的25(OH)D状态。
