类风湿关节炎的表观遗传调控（包括 microRNAs、DNA 甲基化和组蛋白修饰）：系统评价。

Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review.

机构信息

Research Unit 'Etudes en Pharmaco-Immunologie' UR EPI, Université de la Réunion, 97400 Réunion, France.

Orthopedic Clinical Department, CHU Bellepierre, Reunion University Hospital, 97400 Réunion, France.

出版信息

Int J Mol Sci. 2021 Nov 10;22(22):12170. doi: 10.3390/ijms222212170.

DOI:10.3390/ijms222212170

PMID:34830057

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8625518/

Abstract

The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.

摘要

类风湿关节炎（RA）中的炎症反应受主要表观遗传修饰调控，这些修饰可调节滑膜和免疫细胞的表型。本研究的目的是进行系统评价，重点关注 RA 中的 miR 表达、DNA 甲基化和组蛋白修饰。我们证明，在人类样本中，miR-155、miR-146a 和 miR-150 的表达在 RA 组中显著降低，而 miR-410-3p 的表达显著增加。此外，miR-146a 显著降低了 RA 中促自身免疫的 IL-17 细胞因子的表达。在小鼠模型中，miR-34a 的抑制可改善关节炎评分。然而，这一证据仍然远远不足以支持当前 RA 患者的治疗应用。