National Engineering Research Center for Marine Aquaculture, Institute of Innovation & Application, Zhejiang Ocean University, Zhoushan, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Immunol. 2022 Mar 24;13:859400. doi: 10.3389/fimmu.2022.859400. eCollection 2022.
Rheumatoid arthritis (RA) is an autoimmune disease. The etiology of RA remains undetermined and the pathogenesis is complex. There remains a paucity of ideal therapeutic drugs and treatment strategies. The epigenetic modifications affect and regulate the function and characteristics of genes through mechanisms, including DNA methylation, histone modification, chromosome remodeling, and RNAi, thereby exerting a significant impact on the living state of the body. Recently, the phenomenon of epigenetic modification in RA has garnered growing research interest. The application of epigenetically modified methods is the frontier field in the research of RA pathogenesis. This review highlights the research on the pathogenesis of RA based on epigenetic modification in the recent five years, thereby suggesting new methods and strategies for the diagnosis and treatment of RA.
类风湿关节炎（RA）是一种自身免疫性疾病。RA 的病因仍不确定，发病机制复杂。目前仍然缺乏理想的治疗药物和治疗策略。表观遗传修饰通过包括 DNA 甲基化、组蛋白修饰、染色质重塑和 RNAi 在内的机制影响和调节基因的功能和特性，从而对机体的生存状态产生重大影响。最近，RA 中表观遗传修饰的现象引起了越来越多的研究兴趣。应用表观遗传修饰方法是 RA 发病机制研究的前沿领域。本综述重点介绍了近五年来基于表观遗传修饰的 RA 发病机制的研究，从而为 RA 的诊断和治疗提供了新的方法和策略。
