Ku Jeong-Kui, Kim Young-Kyun, Yun Pil-Young
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Section of Dentistry, Armed Forces Capital Dental Hospital, Armed Forces Medical Command, 81, Saemaul-ro 117, Seongnam, 13634 Bundang-gu Korea.
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Gyeonggi-do 463-707 Korea.
Maxillofac Plast Reconstr Surg. 2020 Oct 15;42(1):34. doi: 10.1186/s40902-020-00280-5. eCollection 2020 Dec.
The purpose of this study was to evaluate the influence of biodegradable polycaprolactone membrane on new bone formation and the biodegradation of biphasic alloplastic bone substitutes using animal models.
In this study, bony defect was formed at the canine mandible of 8 mm in diameter, and the defects were filled with Osteon II. The experimental groups were covered with Osteoguide as barrier membrane, and the control groups were closed without membrane coverage. The proportion of new bone and residual bone graft material was measured histologically and histomorphometrically at postoperative 4 and 8 weeks.
At 4 weeks, the new bone proportion was similar between the groups. The proportion of remaining graft volume was 27.58 ± 6.26 and 20.01 ± 4.68% on control and experimental groups, respectively ( < 0.05). There was no significant difference between the two groups in new bone formation and the amount of residual bone graft material at 8 weeks.
The biopolymer membrane contributes to early biodegradation of biphasic bone substitutes in the jaw defect but it does not affect the bone formation capacity of the bone graft.
本研究旨在使用动物模型评估可生物降解的聚己内酯膜对新骨形成的影响以及对双相异体骨替代物生物降解的影响。
在本研究中，在犬下颌骨形成直径为8毫米的骨缺损，并用Osteon II填充缺损。实验组用Osteoguide作为屏障膜覆盖，对照组不使用膜覆盖直接封闭。在术后4周和8周通过组织学和组织形态计量学测量新骨和残余骨移植材料的比例。
在4周时，两组之间的新骨比例相似。对照组和实验组剩余移植体积的比例分别为27.58±6.26%和20.01±4.68%（P<0.05）。在8周时，两组之间在新骨形成和残余骨移植材料量方面没有显著差异。
生物聚合物膜有助于颌骨缺损中双相骨替代物的早期生物降解，但不影响骨移植的骨形成能力。
