Arbune Manuela, Padurariu-Covit Monica-Daniela, Rebegea Laura-Florentina, Lupasteanu Gabriela, Arbune Anca-Adriana, Stefanescu Victorita, Tatu Alin-Laurentiu
Clinical Medical Department, Medicine and Pharmacy Faculty, Dunarea de Jos University of Galati, 800008 Galati, Romania.
Infectious Diseases I Department, Infectious Diseases Clinic Hospital Sf. Cuv. Parascheva, 800179 Galati, Romania.
J Clin Med. 2021 Nov 17;10(22):5346. doi: 10.3390/jcm10225346.
Kaposi's sarcoma (KS) was peculiarly described in the first notified cases of the acquired immunodeficiency syndrome as an opportunistic condition. However, the medical progress and the development of active antiretroviral therapy allowed the control of the HIV/AIDS epidemic, although the features of KS have changed throughout the past decades. The purpose of our study is to assess the epidemiological and clinical features of AIDS related KS in Romanian patients. A retrospective follow-up study was achieved in a single infectious diseases' clinic from Galati-Romania, between 2001 and 2021. Referring to 290 new HIV diagnosed cases from our clinic retained in care, the prevalence of KS was 3.4%. The main characteristics of patients with KS are a median age of 33, a predominance of males, prevalent severe systemic forms of diseases, frequent association of past or concomitant tuberculosis, and context of immune reconstruction syndrome. The mortality rate was 70%. KS has occurred in patients with delayed HIV diagnoses and inadequate adherence to therapy. Early recognition of both infections, the close monitoring of latent or symptomatic tuberculosis, improving the antiretroviral adherence and raising the access to oncologic procedures in Romanian HIV patients could improve their prognosis related to KS.
卡波西肉瘤（KS）在首批报告的获得性免疫缺陷综合征病例中被特别描述为一种机会性疾病。然而，尽管在过去几十年里KS的特征有所变化，但医学的进步和高效抗逆转录病毒疗法的发展使得艾滋病毒/艾滋病疫情得到了控制。我们研究的目的是评估罗马尼亚患者中与艾滋病相关的KS的流行病学和临床特征。2001年至2021年期间，在罗马尼亚加拉茨的一家传染病诊所进行了一项回顾性随访研究。在我们诊所接受治疗的290例新诊断的艾滋病毒病例中，KS的患病率为3.4%。KS患者的主要特征是中位年龄为33岁，男性占主导，普遍存在严重的全身性疾病形式，既往或同时患结核病的情况频繁，以及免疫重建综合征的背景。死亡率为70%。KS发生在艾滋病毒诊断延迟且治疗依从性不足的患者中。早期识别这两种感染，密切监测潜伏性或有症状的结核病，提高抗逆转录病毒治疗的依从性，并增加罗马尼亚艾滋病毒患者获得肿瘤治疗的机会，可能会改善他们与KS相关的预后。
