Tubiana-Mathieu Nicole, Cornette Thibault, Mandigout Stephane, Leobon Sophie, Vincent François, Venat Laurence, Deluche Elise
Department of Medical Oncology, CHU de Limoges, 87000 Limoges, France.
CAPTuR, EA3842, Faculty of Medicine, University Hospital, 87000 Limoges, France.
Cancers (Basel). 2021 Nov 22;13(22):5851. doi: 10.3390/cancers13225851.
Adapted physical activity (APA) aids breast cancer patients. It is necessary to use an adapted target heart rate (HR) when prescribing exercise intensity.
In total, 138 patients previously included in two published randomized clinical trials underwent the CPET and 6MWT before and after adjuvant therapy. Of these patients, 85 had performed APA, and 53 had received only the usual therapy. HRs were recorded during the two tests.
Before starting chemotherapy, good agreement (intraclass correlation (ICC) 0.69; confidence interval at 95% IC (0.591-0.769); < 0.001) and a moderate correlation were evident between the 6MWT-HR and ventilatory threshold HR of the CPET (r = 0.70; < 0.001). Good agreement and a high positive correlation were noted only in the group who engaged in APA (ICC 0.77; IC (0.659-0.848); < 0.001; r = 0.8; < 0.01); moderate agreement and a moderate positive correlation were apparent in the control group (ICC 0.57; IC (0.329-0.74); < 0.001; r = 0.6; < 0.01). The correlations were independent of age and body mass index.
The 6MWT-HR can be used to prescribe exercise intensity for breast cancer patients both before and after specific treatment with concomitant APA.
适应性体育活动（APA）对乳腺癌患者有益。在规定运动强度时，有必要使用适应性目标心率（HR）。
共有138名先前纳入两项已发表随机临床试验的患者在辅助治疗前后接受了心肺运动试验（CPET）和6分钟步行试验（6MWT）。在这些患者中，85名进行了APA，53名仅接受了常规治疗。在两项测试期间记录心率。
在开始化疗前，6MWT心率与CPET的通气阈值心率之间存在良好的一致性（组内相关系数（ICC）为0.69；95%置信区间（IC）为（0.591 - 0.769）；<0.001）和中等程度的相关性（r = 0.70；<0.001）。仅在进行APA的组中观察到良好的一致性和高度正相关（ICC 0.77；IC（0.659 - 0.848）；<0.001；r = 0.8；<0.01）；在对照组中观察到中等程度的一致性和中等程度的正相关（ICC 0.57；IC（0.329 - 0.74）；<0.001；r = 0.6；<0.01）。这些相关性与年龄和体重指数无关。
6MWT心率可用于为接受特定治疗并同时进行APA的乳腺癌患者在治疗前后规定运动强度。
