Center on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing, China.
The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Front Immunol. 2020 Feb 19;11:281. doi: 10.3389/fimmu.2020.00281. eCollection 2020.
The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration. Recently, mounting evidence has suggested that Hippo signaling also has an important role in regulating immunity, including innate and adaptive immune activation. In the neuronal system, Our laboratory results, together with those from other studies, demonstrate that the Hippo signaling pathway is involved in neuroinflammation, neuronal cell differentiation, and neuronal death. In the present review, we summarize the recent findings pertaining to the function and regulatory mechanism of Hippo signaling components in the neuronal system, implicating the potential of Hippo signaling as a therapeutic target for the treatment of neuronal system diseases.
Hippo 信号通路是一种进化上保守的蛋白激酶级联反应，在控制器官大小、癌症发展和组织再生方面发挥着关键作用。最近，越来越多的证据表明 Hippo 信号通路在调节免疫方面也起着重要作用，包括先天免疫和适应性免疫的激活。在神经系统中，我们的实验室结果和其他研究表明 Hippo 信号通路参与神经炎症、神经元细胞分化和神经元死亡。在本综述中，我们总结了 Hippo 信号通路成分在神经系统中的功能和调控机制的最新发现，提示 Hippo 信号通路可能成为治疗神经系统疾病的治疗靶点。
