Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
National Research Council, Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Int J Environ Res Public Health. 2021 Nov 12;18(22):11846. doi: 10.3390/ijerph182211846.
A human biomonitoring (HBM) study on bisphenol A (BPA) in Italian children and adolescents was performed within the LIFE PERSUADED project, considering the residing areas, sex and age. The median urinary BPA level was 7.02 µg/L, with children living in the South of Italy or in urban areas having higher levels than those residing in the North or in rural areas. Children aged 4-6 years had higher BPA levels than those aged 7-10 and 11-14 years, but no differences were detected between sexes. The exposure in Italian children was higher compared to children from other countries, but lower than the HBM guidance value (135 µg/L). The estimated daily intake was 0.17 μg/kg body weight (bw) per day, about 24-fold below the temporary Tolerable Daily Intake of 4 μg/kg bw per day established by the European Food Safety Authority. However, this threshold was exceeded in 1.44% of the enrolled children, raising concern about the overall exposure of Italian young population.
在 LIFE PERSUADED 项目中，针对居住地区、性别和年龄，对意大利儿童和青少年进行了双酚 A（BPA）的人体生物监测（HBM）研究。尿液中 BPA 的中位数水平为 7.02μg/L，居住在意大利南部或城市地区的儿童的 BPA 水平高于居住在北部或农村地区的儿童。4-6 岁的儿童的 BPA 水平高于 7-10 岁和 11-14 岁的儿童，但男女之间没有差异。与其他国家的儿童相比，意大利儿童的暴露水平较高，但低于人体生物监测指导值（135μg/L）。估计的每日摄入量为 0.17μg/kg 体重（bw）/天，约为欧洲食品安全局规定的 4μg/kg bw/天临时耐受每日摄入量的 24 倍。然而，在 1.44%的入组儿童中，这一阈值被超过，这引发了对意大利年轻人群体总体暴露的担忧。
