Department of Nursing, College of Nursing, Gachon University, 191 Hambakmoeiro, Yeonsu-gu, Incheon City 21936, Korea.
Department of Preventive Medicine, College of Medicine, Korea University, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
Int J Environ Res Public Health. 2019 Jul 15;16(14):2521. doi: 10.3390/ijerph16142521.
Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: -0.121 to 0.453, = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.
双酚 A（BPA）是一种对健康有害的环境化学物质，可能导致儿童肥胖。然而，这种关联仍然存在争议，并且很难通过流行病学研究找到环境暴露与疾病之间存在直接因果关系的证据。在这项研究中，我们试图通过进行两项荟萃分析来阐明 BPA 暴露与儿童肥胖之间可能存在的因果关系，这两项荟萃分析显示了双向关联，包括肥胖对暴露的影响和暴露对肥胖风险的影响。我们在 PubMed、Embase 和 Cochrane Library 中搜索了截至 2017 年 9 月发表的文章。我们评估了包括尿 BPA 浓度和 BMI 或体重测量的观察性研究。在 436 篇文章中，共有 13 项研究纳入荟萃分析。进行了两项荟萃分析，以调查 BPA 暴露与儿童肥胖之间的关联。结果表明，高暴露组患儿童肥胖的风险明显高于低暴露组（比值比=1.566，95%置信区间[CI]：1.097 至 2.234，=0.014）。然而，与正常组相比，肥胖组的 BPA 浓度没有显著差异（标准化均数差=0.166，95%CI：-0.121 至 0.453，=0.257）。这项研究使用来自流行病学研究的数据表明，BPA 暴露与儿童肥胖之间可能存在因果关系，并且 BPA 暴露本身增加了儿童肥胖的风险。
