Frytak S, Moertel C G, Childs D S, Schutt A J, Albers J W
Cancer Treat Rep. 1978 Mar;62(3):483-5.
Thirty-two patients with advanced carcinoma of the colon or rectum were given metronidazole orally at a dose of 500-1000 mg/m2 three times a day for 7 consecutive days every 6 weeks. The dose-limiting toxic effects consisted of severe nausea, vomiting, and major motor seizures. Mild peripheral neurotoxic effects were also noted. No objective responses were noted in any of the 32 patients treated. High-dose metronidazole would not seem to have any role in the treatment of advanced colorectal carcinoma and may cause serious neurotoxicity.
32例晚期结肠癌或直肠癌患者口服甲硝唑，剂量为500 - 1000mg/m²，每日3次，连续7天，每6周重复一次。剂量限制性毒性反应包括严重恶心、呕吐和严重运动性癫痫发作。还观察到轻度周围神经毒性反应。接受治疗的32例患者均未出现客观缓解。高剂量甲硝唑似乎对晚期结直肠癌的治疗没有任何作用，且可能导致严重神经毒性。
