Centro de Investigación Mariña, Departamento de Química Analítica e Alimentaria, Campus de Vigo, Universidade de Vigo, Grupo QA2, Edificio CC Experimentais, As Lagoas, Marcosende, 36310 Vigo, Spain.
Sensors (Basel). 2021 Nov 14;21(22):7571. doi: 10.3390/s21227571.
Lab-on-paper technologies, also known as paper-based analytical devices (PADs), have received increasing attention in the last years, and nowadays, their use has spread to virtually every application area, i.e., medical diagnostic, food safety, environmental monitoring, etc. Advantages inherent to on-field detection, which include avoiding sampling, sample preparation and conventional instrumentation in central labs, are undoubtedly driving many developments in this area. Heavy metals represent an important group of environmental pollutants that require strict controls due to the threat they pose to ecosystems and human health. In this overview, the development of PADs for Hg monitoring, which is considered the most toxic metal in the environment, is addressed. The main emphasis is placed on recognition elements (i.e., organic chromophores/fluorophores, plasmonic nanoparticles, inorganic quantum dots, carbon quantum dots, metal nanoclusters, etc.) employed to provide suitable selectivity and sensitivity. The performance of both microfluidic paper-based analytical devices and paper-based sensors using signal readout by colorimetry and luminescence will be discussed.
近年来，纸质分析器件（PADs），也被称为纸上实验室技术，受到了越来越多的关注。如今，它的应用几乎已经扩展到了每一个领域，例如医学诊断、食品安全、环境监测等。现场检测的优势，包括避免在中央实验室进行采样、样品制备和常规仪器检测，无疑推动了该领域的许多发展。重金属是一类重要的环境污染物，由于它们对生态系统和人类健康构成的威胁，需要严格加以控制。在这篇综述中，我们探讨了用于汞监测的 PAD 的发展情况，汞被认为是环境中最具毒性的金属。重点是用于提供适当选择性和灵敏度的识别元件（即有机生色团/荧光团、等离子体纳米粒子、无机量子点、碳量子点、金属纳米簇等）。我们将讨论使用比色法和荧光法进行信号读取的微流控纸质分析器件和纸质传感器的性能。
