直接光激发苯并噻唑啉：酰基自由基的生成及其在杂环合成中的应用。
Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles.
机构信息
Anhui Province Key Laboratory of Chemistry for Inorganic, Organic Hybrid Functionalized Materials, College of Chemistry & Chemical Engineering, Anhui University, Hefei 230601, China.
Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Hefei 230601, China.
出版信息
Molecules. 2021 Nov 12;26(22):6843. doi: 10.3390/molecules26226843.
An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.
通过直接光激发苯并噻唑啉，开发了一种酰基自由基生成和功能化策略。形成的酰基自由基可以被喹喔啉-2-酮捕获，实现 C(3)-H 官能化，或者与异腈引发级联自由基环化反应，合成具有重要生物学意义的菲啶。该方法的合成价值可以通过喹喔啉-2-酮的修饰进一步说明，其中包含重要的天然产物和基于药物的复杂分子。
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