Trnovec T, Bezek S, Gajdosík A, Sikl D
Circ Shock. 1978;5(1):51-9.
Fever and shock are symptoms of acute disseminated candidiasis. Phagocytic activity of the reticuloendothelial system (RES), following a single administration of polysaccharide-protein complex, was studied with respect to the role of the RES in the pathophysiology of circulatory shock. The index of phagocytic activity was determined 15 or 120 minutes following IV administration of polysaccharide-protein complex (50 mg/kg) to mice, from the rates of clearance of carbon particles and of heterologous erythrocytes labeled with 51Cr. The mice were pretreated with hydrocortisone 300 mg/kg, methylprednisolone, 30 mg/kg, or saline 120 minutes before administration of the polysaccharide-protein complex. Depression of the phagocytic activity was observed following administration of polysaccharide-protein complex in both time intervals investigated. This depression could be prevented successfully by administration of both glucocorticoids studied. The fractional distribution of 86Rb was determined in other groups of identically treated mice. An increase of 86Rb uptake was found in the heart, lungs, and adrenals 15 minutes after administration of polysaccharide-protein complex. A decrease of 86Rb uptake was found in the intestines and spleen. These changes were also found in mice pretreated with glucocorticoids. A return to the normal picture of 86Rb fractional distribution was found 120 minutes after polysaccharide-protein administration. It was suggested that changes in phagocytic activity were not a result of altered hemodynamics.
发热和休克是急性播散性念珠菌病的症状。在单次给予多糖-蛋白质复合物后，针对网状内皮系统（RES）在循环性休克病理生理学中的作用，对其吞噬活性进行了研究。通过碳颗粒清除率和用51Cr标记的异源红细胞清除率，在给小鼠静脉注射多糖-蛋白质复合物（50mg/kg）后15或120分钟测定吞噬活性指数。在给予多糖-蛋白质复合物前120分钟，用300mg/kg氢化可的松、30mg/kg甲基泼尼松龙或生理盐水对小鼠进行预处理。在研究的两个时间间隔内，给予多糖-蛋白质复合物后均观察到吞噬活性降低。所研究的两种糖皮质激素给药均可成功预防这种降低。在其他相同处理的小鼠组中测定86Rb的分数分布。给予多糖-蛋白质复合物15分钟后，心脏、肺和肾上腺中86Rb摄取增加。在肠道和脾脏中发现86Rb摄取减少。在用糖皮质激素预处理的小鼠中也发现了这些变化。给予多糖-蛋白质复合物120分钟后，86Rb分数分布恢复正常。有人提出吞噬活性的变化不是血流动力学改变的结果。
