Melgaço Fabiana Gil, Azamor Tamiris, Villar Livia Melo, Ano Bom Ana Paula Dinis, Melgaço Juliana Gil
Laboratório de Cultu and s Biológicas, Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Duque de Caxias 25050-100, Brazil.
Instituto de Tecnologia em Imunobiológicos, Bio-Manguinhos, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, Brazil.
Viruses. 2021 Oct 24;13(11):2143. doi: 10.3390/v13112143.
Vaccines to prevent the impact of SARS-CoV-2 are now available, including for patients with autoimmune diseases. However, there is no information about how inflammatory bowel disease (IBD) treatment could impact the cellular and humoral immune responses. This study evaluated SARS-CoV-2-specific humoral and cellular responses after vaccination with a two-dose schedule in a Crohn's disease patient treated with Infliximab (10 mg/kg); we included comparisons with a monozygotic twin. The results showed that the Crohn's disease's twin (twin 2) had no antibody detection and reduced activation of CD4+ T cell responses, unlike the twin without the autoimmune disease (twin 1). Twin 2 developed antigen-specific central memory CD8+ T-cells and IFNγ production after the second dose of COVID-19 vaccination, similar to twin 1. These findings elucidated the role of T-cell immunity after COVID-19 immunization on IBD patients despite the lack of antibody production. Finally, our observation supports the consensus recommendation for IBD patients to receive COVID-19 vaccines.
目前已有预防严重急性呼吸综合征冠状病毒2（SARS-CoV-2）影响的疫苗，包括针对自身免疫性疾病患者的疫苗。然而，关于炎症性肠病（IBD）治疗如何影响细胞免疫和体液免疫反应尚无相关信息。本研究评估了在接受英夫利昔单抗（10mg/kg）治疗的克罗恩病患者中，按照两剂接种方案接种疫苗后针对SARS-CoV-2的体液免疫和细胞免疫反应；我们纳入了与同卵双胞胎的比较。结果显示，与没有自身免疫性疾病的双胞胎（双胞胎1）不同，患有克罗恩病的双胞胎（双胞胎2）未检测到抗体，且CD4+T细胞反应的激活降低。双胞胎2在接种第二剂2019冠状病毒病疫苗后产生了抗原特异性中枢记忆CD8+T细胞并分泌γ干扰素，与双胞胎1相似。尽管未产生抗体，但这些发现阐明了2019冠状病毒病免疫接种后T细胞免疫在IBD患者中的作用。最后，我们的观察结果支持针对IBD患者接种2019冠状病毒病疫苗的共识性建议。
