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在 COVID-19 大流行期间如何管理炎症性肠病:临床医生实用指南。

How to manage inflammatory bowel disease during the COVID-19 pandemic: A guide for the practicing clinician.

机构信息

Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, Federal University of Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil.

Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo 05403-000, SP, Brazil.

出版信息

World J Gastroenterol. 2021 Mar 21;27(11):1022-1042. doi: 10.3748/wjg.v27.i11.1022.

Abstract

Managing inflammatory bowel disease (IBD) during the coronavirus disease 2019 (COVID-19) pandemic has been a challenge faced by clinicians and their patients, especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). The knowledge about the impact of this virus on patients with IBD, although it is still scarce, is rapidly evolving. In particular, concerns surrounding medications' impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19, and potentially exacerbate viral replication and the COVID-19 course, are a current thinking of both practicing clinicians and providers caring for patients with IBD. Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19. In this review, we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection, and the COVID-19 impact on both the patient's psychological functioning and endoscopy services, and we concisely summarize the telemedicine roles during the COVID-19 pandemic.

摘要

管理炎症性肠病(IBD)在 2019 年冠状病毒病(COVID-19)大流行期间一直是临床医生及其患者面临的挑战,特别是在全球爆发高度传染性新型冠状病毒(严重急性呼吸系统综合征冠状病毒 2,SARS-CoV-2)的背景下,是否继续使用生物制剂和免疫抑制剂。尽管关于这种病毒对 IBD 患者的影响的知识仍然很少,但它正在迅速发展。特别是,围绕药物对 IBD 患者感染 SARS-CoV-2 的风险或发展 COVID-19 的风险,以及潜在地加剧病毒复制和 COVID-19 病程的担忧,是目前临床医生和为 IBD 患者提供护理的提供者关注的问题。管理感染 SARS-CoV-2 的 IBD 患者取决于 IBD 的临床活动以及 COVID-19 的偶发发生和严重程度。在这篇综述中,我们总结了有关 SARS-CoV-2 对胃肠道的影响以及针对这种感染的 IBD 的药物和手术管理的现有数据,以及 COVID-19 对患者心理功能和内镜服务的影响,并简要总结了 COVID-19 大流行期间远程医疗的作用。

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