Karrow Niel A, Shandilya Umesh K, Pelech Steven, Wagter-Lesperance Lauraine, McLeod Deanna, Bridle Byram, Mallard Bonnie A
Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Vaccines (Basel). 2021 Nov 18;9(11):1351. doi: 10.3390/vaccines9111351.
Vaccines have been developed at "warp speed" to combat the COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Although they are considered the best approach for preventing mortality, when assessing the safety of these vaccines, pregnant women have not been included in clinical trials. Thus, vaccine safety for this demographic, as well as for the developing fetus and neonate, remains to be determined. A global effort has been underway to encourage pregnant women to get vaccinated despite the uncertain risk posed to them and their offspring. Given this, post-hoc data collection, potentially for years, will be required to determine the outcomes of COVID-19 and vaccination on the next generation. Most COVID-19 vaccine reactions include injection site erythema, pain, swelling, fatigue, headache, fever and lymphadenopathy, which may be sufficient to affect fetal/neonatal development. In this review, we have explored components of the first-generation viral vector and mRNA COVID-19 vaccines that are believed to contribute to adverse reactions and which may negatively impact fetal and neonatal development. We have followed this with a discussion of the potential for using an ovine model to explore the long-term outcomes of COVID-19 vaccination during the prenatal and neonatal periods.
疫苗已以“极快的速度”研发出来，以对抗由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的新冠疫情。尽管疫苗被认为是预防死亡的最佳方法，但在评估这些疫苗的安全性时，孕妇并未被纳入临床试验。因此，这类人群以及发育中的胎儿和新生儿的疫苗安全性仍有待确定。尽管给孕妇及其后代带来的风险尚不确定，但全球一直在努力鼓励孕妇接种疫苗。鉴于此，可能需要进行数年的事后数据收集，以确定新冠病毒和疫苗接种对下一代的影响。大多数新冠疫苗反应包括注射部位红斑、疼痛、肿胀、疲劳、头痛、发热和淋巴结病，这些可能足以影响胎儿/新生儿的发育。在这篇综述中，我们探讨了第一代病毒载体和信使核糖核酸新冠疫苗的成分，这些成分被认为会导致不良反应，并且可能对胎儿和新生儿发育产生负面影响。在此之后，我们讨论了使用绵羊模型探索产前和新生儿期新冠疫苗接种长期结果的可能性。
