Mohiuddin Sayed Golam, Ghosh Sreyashi, Ngo Han G, Sensenbach Shayne, Karki Prashant, Dewangan Narendra K, Angardi Vahideh, Orman Mehmet A
Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77004, USA.
Microorganisms. 2021 Oct 31;9(11):2269. doi: 10.3390/microorganisms9112269.
Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells that enables survival under stressful conditions by recycling essential energy molecules. Self-digestion, which is triggered by extracellular stress conditions, such as nutrient depletion and overpopulation, induces degradation of intracellular components. This self-inflicted damage renders the bacterium less fit to produce building blocks and resume growth upon exposure to fresh nutrients. However, self-digestion may also provide temporary protection from antibiotics until the self-digestion-mediated damage is repaired. In fact, many persistence mechanisms identified to date may be directly or indirectly related to self-digestion, as these processes are also mediated by many degradative enzymes, including proteases and ribonucleases (RNases). In this review article, we will discuss the potential roles of self-digestion in bacterial persistence.
细胞自我消化是原核细胞中一种进化上保守的过程，它通过循环利用必需的能量分子，使细胞在应激条件下得以存活。由细胞外应激条件（如营养物质耗尽和过度增殖）引发的自我消化会诱导细胞内成分的降解。这种自我造成的损伤使细菌不太适合生产构建模块并在接触新鲜营养物质后恢复生长。然而，自我消化也可能对抗生素提供暂时的保护，直到自我消化介导的损伤得到修复。事实上，迄今为止确定的许多持续性机制可能直接或间接地与自我消化有关，因为这些过程也由许多降解酶介导，包括蛋白酶和核糖核酸酶（RNase）。在这篇综述文章中，我们将讨论自我消化在细菌持续性中的潜在作用。
