Carbapenemase-Producing Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study.

Carbapenemase-KPC producing (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP- with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP--related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP--related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality.