DIMES-Section of Biochemistry, University of Genova, 16132 Genova, Italy.
Buck Institute for Research on Aging, Novato, CA 94945, USA.
Nutrients. 2021 Oct 23;13(11):3734. doi: 10.3390/nu13113734.
Nicotinamide adenine dinucleotide (NAD) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD degrading enzymes. Among these enzymes, CD38 can be seen under two perspectives: as the enzyme synthesizing Ca-mobilizing second messenger, starting from NAD, and as the major NAD-consumer, to be inhibited to increase NAD levels. Indeed, the regulation of NAD availability is a key event during different processes. In this review, we examine the recent studies related to the modulation of CD38 expression and activity, and the consequent changes in NAD(P)(H), in adipose tissue, during inflammation and cold-induced thermogenesis.
烟酰胺腺嘌呤二核苷酸（NAD）是调节能量代谢的基本分子，既是辅酶，也是不同 NAD 降解酶的底物。在这些酶中，CD38 可以从两个角度来看待：作为从 NAD 开始合成钙动员第二信使的酶，以及作为主要的 NAD 消耗酶，通过抑制它来增加 NAD 水平。事实上，NAD 可用性的调节是不同过程中的关键事件。在这篇综述中，我们检查了与 CD38 表达和活性的调节以及 NAD(P)(H)在脂肪组织中的变化相关的最近研究，这些变化发生在炎症和冷诱导产热期间。
