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1
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Cell Metab. 2016 Jun 14;23(6):1127-1139. doi: 10.1016/j.cmet.2016.05.006.
2
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.
Aging Cell. 2022 Apr;21(4):e13589. doi: 10.1111/acel.13589. Epub 2022 Mar 8.
3
The NADase CD38 may not dictate NAD levels in brain mitochondria of aged mice but regulates hydrogen peroxide generation.
Free Radic Biol Med. 2023 Nov 20;209(Pt 1):29-39. doi: 10.1016/j.freeradbiomed.2023.09.035. Epub 2023 Sep 28.
4
Regulation of intracellular levels of NAD: a novel role for CD38.
Biochem Biophys Res Commun. 2006 Jul 14;345(4):1386-92. doi: 10.1016/j.bbrc.2006.05.042. Epub 2006 May 15.
5
Senescent cells promote tissue NAD decline during ageing via the activation of CD38 macrophages.
Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16.
7
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels.
Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16.
8
Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice.
J Neurosci Res. 2019 Aug;97(8):975-990. doi: 10.1002/jnr.24397. Epub 2019 Feb 23.
9
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD decline.
Biochem Biophys Res Commun. 2019 May 28;513(2):486-493. doi: 10.1016/j.bbrc.2019.03.199. Epub 2019 Apr 8.
10
Enzyme properties of Aplysia ADP-ribosyl cyclase: comparison with NAD glycohydrolase of CD38 antigen.
J Biochem. 1995 Jan;117(1):125-31. doi: 10.1093/oxfordjournals.jbchem.a124698.

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Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer.
Nat Rev Cancer. 2025 Sep 8. doi: 10.1038/s41568-025-00868-x.
2
Protein Acetylation and NAD+ Homeostasis in Aging Muscle.
Adv Exp Med Biol. 2025;1478:421-443. doi: 10.1007/978-3-031-88361-3_17.
3
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes.
Exp Mol Med. 2025 Aug;57(8):1861-1877. doi: 10.1038/s12276-025-01521-1. Epub 2025 Aug 25.
4
Estrogens protect bone mass by inhibiting NAD metabolism in osteoclasts.
bioRxiv. 2025 Jul 16:2025.07.11.664289. doi: 10.1101/2025.07.11.664289.
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Nicotinamide phosphoribosyltransferase in NAD metabolism: physiological and pathophysiological implications.
Cell Death Discov. 2025 Aug 8;11(1):371. doi: 10.1038/s41420-025-02672-w.
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The role of NAD metabolism and its modulation of mitochondria in aging and disease.
NPJ Metab Health Dis. 2025 Jun 18;3(1):26. doi: 10.1038/s44324-025-00067-0.

本文引用的文献

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Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice.
BMC Microbiol. 2016 Jan 16;16:9. doi: 10.1186/s12866-016-0625-7.
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Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model.
Ann Neurol. 2015 Jul;78(1):88-103. doi: 10.1002/ana.24425. Epub 2015 May 25.
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Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.
J Med Chem. 2015 Apr 23;58(8):3548-71. doi: 10.1021/jm502009h. Epub 2015 Apr 10.
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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences.
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2876-81. doi: 10.1073/pnas.1417921112. Epub 2015 Feb 17.
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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Cell Metab. 2014 Nov 4;20(5):840-855. doi: 10.1016/j.cmet.2014.10.005.
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Elevated muscle TLR4 expression and metabolic endotoxemia in human aging.
J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):232-46. doi: 10.1093/gerona/glu067. Epub 2014 May 20.
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Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.
Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2261-70. doi: 10.1073/pnas.1320843111. Epub 2014 May 19.
8
NAD+ and sirtuins in aging and disease.
Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29.
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NAD+ deficiency in age-related mitochondrial dysfunction.
Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.

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