Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University, Faculté de Médecine-Secteur Timone, EA 3279: CEReSS-Centre d'Etude et de Recherche sur les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005 Marseille, France.
Fondation Fonda Mental, 94000 Créteil, France.
Nutrients. 2021 Nov 5;13(11):3947. doi: 10.3390/nu13113947.
Fasting interventions have shown effectiveness in alleviating stress, anxiety and depressive symptoms. However, no quantitative analysis has been carried out thus far. The objective was to determine the effectiveness of fasting interventions on stress, anxiety and depression and if these interventions were associated with increased or decreased fatigue/energy.
Overall, 11 studies and 1436 participants were included in the quantitative analyses.
After limiting analyses to randomized controlled trials with low risk of bias, we found that fasting groups had lower anxiety (b = -0.508, = 0.038), depression levels (b= -0.281, = 0.012) and body mass index compared to controls without increased fatigue. There was no publication bias and no heterogeneity for these results. These interventions were safe, even in patients with type 2 diabetes.
These results should be taken with a caveat. These results are preliminary and encouraging and fasting appears to be a safe intervention. Data are not sufficient to recommend one fasting intervention more than the others. No study was carried out in psychiatric populations and further trials should be carried out in these populations that may be good candidates for fasting interventions.
禁食干预已被证明能有效缓解压力、焦虑和抑郁症状。然而，目前还没有进行定量分析。本研究旨在确定禁食干预对压力、焦虑和抑郁的有效性，以及这些干预是否与疲劳/能量的增加或减少有关。
共纳入 11 项研究和 1436 名参与者进行定量分析。
在将分析仅限于低偏倚风险的随机对照试验后，我们发现与对照组相比，禁食组的焦虑（b = -0.508， = 0.038）、抑郁水平（b = -0.281， = 0.012）和体重指数更低，且不会增加疲劳感。这些结果没有发表偏倚，也没有异质性。这些干预措施是安全的，即使是 2 型糖尿病患者也可以接受。
这些结果应该谨慎对待。这些结果是初步的，令人鼓舞的，禁食似乎是一种安全的干预措施。目前还没有足够的数据来推荐一种禁食干预措施优于其他方法。没有研究在精神科人群中进行，因此应该在这些可能是禁食干预良好候选者的人群中进行进一步的试验。
