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精氨酸与 COVID-19:最新进展。

l-Arginine and COVID-19: An Update.

机构信息

Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA.

Department of Molecular Pharmacology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY 10461, USA.

出版信息

Nutrients. 2021 Nov 5;13(11):3951. doi: 10.3390/nu13113951.

DOI:10.3390/nu13113951
PMID:34836206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8619186/
Abstract

l-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.

摘要

精氨酸参与许多不同的生物过程,最近的报告表明,它在由严重急性呼吸系统综合征冠状病毒 2 型(SARS-CoV-2)引起的 2019 年冠状病毒病(COVID-19)中也可能发挥关键作用。在此,我们对目前关于精氨酸在 COVID-19 中的功能贡献的证据进行了更新的系统综述,描述了它对血管内皮细胞和免疫系统的作用,并讨论了它作为一种治疗工具的潜力,这是最近的临床实验中出现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d793/8619186/b68a5d6a0d1d/nutrients-13-03951-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d793/8619186/bfd7e5ac8790/nutrients-13-03951-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d793/8619186/b68a5d6a0d1d/nutrients-13-03951-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d793/8619186/bfd7e5ac8790/nutrients-13-03951-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d793/8619186/b68a5d6a0d1d/nutrients-13-03951-g002.jpg

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3
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4
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Amino Acids. 2025 May 7;57(1):24. doi: 10.1007/s00726-025-03453-6.
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