Bioinformatics and Biostatistics Unit, Department of Applied Research and Technological Development, Fondazione IRCSS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Unit of Epidemiology and Prevention, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Nutrients. 2021 Nov 9;13(11):3988. doi: 10.3390/nu13113988.
A total colectomy and a frequent life-long endoscopic surveillance are guaranteed to patients with Familial Adenomatous Polyposis (FAP) to reduce their risk of duodenal and rectal stump cancers. However, after surgery, individuals with FAP suffer from an increased number of diarrheal discharges that force them to dietary restrictions. A non-randomized pilot study was conducted to assess whether a three-month low-inflammatory Mediterranean dietary intervention reduces gastro-intestinal markers of inflammation in FAP individuals. The aim of the present work is to evaluate the participant's adherence to the proposed dietary recommendations and the change in their number of diarrheal discharges.
26 FAP individuals aged >18 years, who underwent a total colectomy with ileo-rectal anastomosis and were involved in the surveillance program at the Fondazione IRCCS Istituto Nazionale Tumori of Milan, were included in the present analysis.
FAP individuals significantly reduced the foods (-value: 0.002) and increased the consumption of the ones (-value: 0.075). The adherence to the proposed dietary recommendations was accompanied by a significant decrease in the number of diarrheal discharges (-value: 0.008).
This study suggests that adhering to a low-inflammatory Mediterranean diet has a potential protective effect on the number of diarrheal discharges in FAP individuals.
家族性腺瘤性息肉病（FAP）患者需要进行全结肠切除术和长期频繁的内镜监测，以降低十二指肠和直肠残端癌的风险。然而，手术后，FAP 患者会出现更多的腹泻，这迫使他们限制饮食。一项非随机试点研究旨在评估为期三个月的低炎症性地中海饮食干预是否能降低 FAP 个体的胃肠炎症标志物。本研究旨在评估参与者对所建议饮食建议的依从性以及腹泻次数的变化。
本分析纳入了 26 名年龄>18 岁的 FAP 个体，他们接受了全结肠切除术和回肠直肠吻合术，并参与了米兰国家肿瘤研究所 IRCCS 基金会的监测计划。
FAP 个体显著减少了 类食物（-值：0.002），增加了 类食物的摄入（-值：0.075）。对建议饮食建议的依从性伴随着腹泻次数的显著减少（-值：0.008）。
本研究表明，遵循低炎症性地中海饮食对 FAP 个体的腹泻次数可能具有潜在的保护作用。
