Department of Paediatric Endoscopy and Gastrointestinal Function Testing, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, ul. Jagiellonska 13-15, 85-067 Bydgoszcz, Poland.
Nutrients. 2021 Nov 11;13(11):4027. doi: 10.3390/nu13114027.
The differential diagnosis and treatment of seronegative enteropathy, also termed seronegative villous atrophy (SNVA), is a clinical challenge. Although seronegative coeliac disease (CD) is a frequent cause of SNVA, the aetiology can include immune-mediated, inflammatory, infectious, and drug-related forms. As a misdiagnosis of SNVA can result in patients being unnecessarily placed on a lifelong strict gluten-free diet or even given incorrect immunosuppressive therapy, the aim of this paper is to provide an evidence-based and practical approach for the workup and management of SNVA.
血清阴性肠病（也称血清阴性绒毛萎缩症，SNVA）的鉴别诊断和治疗是一项临床挑战。虽然血清阴性乳糜泻（CD）是 SNVA 的常见病因，但病因还包括免疫介导、炎症、感染和药物相关等形式。由于误诊 SNVA 可能导致患者不必要地长期严格遵循无麸质饮食，甚至给予错误的免疫抑制治疗，因此本文旨在为 SNVA 的检查和管理提供循证和实用的方法。
