定义反复着床失败：困惑丛生还是纯属臆想？
Defining recurrent implantation failure: a profusion of confusion or simply an illusion?
机构信息
Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
出版信息
Fertil Steril. 2021 Dec;116(6):1432-1435. doi: 10.1016/j.fertnstert.2021.10.023.
Abstract
Recurrent implantation failure (RIF) is a poorly defined clinical scenario marked by failure to achieve pregnancy after multiple embryo transfers. The causes and definitions of implantation failure are heterogeneous, posing limitations on study design as well as the interpretation and application of findings. Recent studies suggest a novel, personalized approach to defining RIF. Here, we review the implantation physiology and definitions of the implantation rate, failure, and RIF.
摘要
反复着床失败（RIF）是一种定义不明确的临床情况，其特征是多次胚胎移植后仍未能妊娠。着床失败的原因和定义存在异质性，这对研究设计以及研究结果的解释和应用都构成了限制。最近的研究提出了一种新颖的、个性化的定义 RIF 的方法。在此，我们回顾了着床生理学以及着床率、失败和 RIF 的定义。
相似文献
1
Defining recurrent implantation failure: a profusion of confusion or simply an illusion?定义反复着床失败：困惑丛生还是纯属臆想？
Fertil Steril. 2021 Dec;116(6):1432-1435. doi: 10.1016/j.fertnstert.2021.10.023.
2
A review of the pathophysiology of recurrent implantation failure.复发性植入失败的病理生理学综述。
Fertil Steril. 2021 Dec;116(6):1436-1448. doi: 10.1016/j.fertnstert.2021.09.014. Epub 2021 Oct 19.
3
Recurrent implantation failure: a comprehensive review.反复种植失败：全面综述
Minerva Ginecol. 2016 Dec;68(6):653-67. Epub 2016 Mar 16.
4
Novel therapeutic options for treatment of recurrent implantation failure.治疗反复种植失败的新型治疗选择。
Fertil Steril. 2021 Dec;116(6):1449-1454. doi: 10.1016/j.fertnstert.2021.10.025.
5
Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure.评估子宫内膜容受性检测和胚胎植入前非整倍体基因检测在克服反复种植失败中的作用。
J Assist Reprod Genet. 2020 Dec;37(12):2989-2997. doi: 10.1007/s10815-020-01948-7. Epub 2020 Sep 24.
6
Endometrial Receptivity Analysis - a tool to increase an implantation rate in assisted reproduction.子宫内膜容受性分析——一种提高辅助生殖中着床率的工具。
Ceska Gynekol. 2019 Spring;84(3):177-183.
7
Recurrent implantation failure: A comprehensive summary from etiology to treatment.反复种植失败：从病因到治疗的全面总结。
Front Endocrinol (Lausanne). 2023 Jan 5;13:1061766. doi: 10.3389/fendo.2022.1061766. eCollection 2022.
8
What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study.两天的变化有多大：“个性化”胚胎移植 (pET) 范例：病例报告和初步研究。
Hum Reprod. 2014 Jun;29(6):1244-7. doi: 10.1093/humrep/deu070. Epub 2014 Apr 15.
9
MicroRNA signatures in plasma and plasma exosome during window of implantation for implantation failure following in-vitro fertilization and embryo transfer.在体外受精和胚胎移植后着床失败的窗口期，血浆和血浆外泌体中的 microRNA 特征。
Reprod Biol Endocrinol. 2021 Dec 7;19(1):180. doi: 10.1186/s12958-021-00855-5.
10
Endometrium Immunomodulation to Prevent Recurrent Implantation Failure in Assisted Reproductive Technology.子宫内膜免疫调节以预防辅助生殖技术中的反复着床失败。
Int J Mol Sci. 2022 Oct 24;23(21):12787. doi: 10.3390/ijms232112787.
引用本文的文献
1
Establishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure.基于RNA测序的复发性植入失败患者植入精确时间窗预测模型的建立与应用
J Assist Reprod Genet. 2025 Apr 30. doi: 10.1007/s10815-025-03468-8.
2
Personalized embryo transfer guided by rsERT improves pregnancy outcomes in patients with repeated implantation failure.由rsERT引导的个性化胚胎移植可改善反复种植失败患者的妊娠结局。
Front Med (Lausanne). 2024 May 15;11:1369317. doi: 10.3389/fmed.2024.1369317. eCollection 2024.
3
Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2.NSD2 表达降低通过重编程 H3K36me2 来损害人子宫内膜间质细胞增殖。
Reproduction. 2024 Feb 12;167(3). doi: 10.1530/REP-23-0254. Print 2024 Mar 1.
4
Novel embryo selection strategies-finding the right balance.新型胚胎选择策略——寻求恰当平衡
Front Reprod Health. 2023 Dec 15;5:1287621. doi: 10.3389/frph.2023.1287621. eCollection 2023.
5
Reactive Oxygen Species Damage Bovine Endometrial Epithelial Cells via the Cytochrome C-mPTP Pathway.活性氧通过细胞色素C-线粒体通透性转换孔途径损伤牛子宫内膜上皮细胞。
Antioxidants (Basel). 2023 Dec 16;12(12):2123. doi: 10.3390/antiox12122123.
6
Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.富血小板血浆对有胚胎移植失败史女性的疗效：一项采用序贯试验分析的系统评价和荟萃分析
Bioengineering (Basel). 2023 Feb 27;10(3):303. doi: 10.3390/bioengineering10030303.
7
Human Leukocyte Antigen Alleles Compatibility and Immunophenotypic Profile Associations in Infertile Couples.不育夫妇中人类白细胞抗原等位基因相容性与免疫表型特征的关联
Cureus. 2023 Mar 23;15(3):e36584. doi: 10.7759/cureus.36584. eCollection 2023 Mar.
8
An In Vivo Screening Model for Investigation of Pathophysiology of Human Implantation Failure.一种用于研究人类着床失败病理生理学的体内筛选模型。
Biomolecules. 2022 Dec 30;13(1):79. doi: 10.3390/biom13010079.
9
Does antibiotic therapy for chronic endometritis improve clinical outcomes of patients with recurrent implantation failure in subsequent IVF cycles? A systematic review and meta-analysis.慢性子宫内膜炎的抗生素治疗是否能改善反复种植失败患者在随后的 IVF 周期中的临床结局？系统评价和荟萃分析。
J Assist Reprod Genet. 2022 Aug;39(8):1797-1813. doi: 10.1007/s10815-022-02558-1. Epub 2022 Jul 13.
本文引用的文献
1
A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age.基于女性年龄对应的预期囊胚非整倍体率，对复发性植入失败进行新的定义。
Fertil Steril. 2021 Nov;116(5):1320-1327. doi: 10.1016/j.fertnstert.2021.06.045. Epub 2021 Jul 28.
2
An algorithm to personalise the diagnosis of recurrent implantation failure based on theoretical cumulative implantation rate.基于理论累积种植率的个体化复发性种植失败诊断算法。
Hum Reprod. 2021 May 17;36(6):1463-1468. doi: 10.1093/humrep/deab091.
3
Endometrial thickness is not predictive for live birth after embryo transfer, even without a cutoff.子宫内膜厚度对胚胎移植后活产没有预测作用，即使没有截止值。
Fertil Steril. 2021 Jul;116(1):130-137. doi: 10.1016/j.fertnstert.2021.02.041. Epub 2021 Mar 31.
4
The prolonged disease state of infertility is associated with embryonic epigenetic dysregulation.不孕的长期疾病状态与胚胎表观遗传失调有关。
Fertil Steril. 2021 Aug;116(2):309-318. doi: 10.1016/j.fertnstert.2021.01.040. Epub 2021 Mar 19.
5
Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers.放下过去：女性的生殖史与囊胚的整倍体率无关，与整倍体胚胎移植后的活产率关联有限。
Hum Reprod. 2021 Mar 18;36(4):929-940. doi: 10.1093/humrep/deab014.
6
Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists.复发性种植失败的定义、诊断和治疗选择：对临床医生和胚胎学家的国际调查。
Hum Reprod. 2021 Jan 25;36(2):305-317. doi: 10.1093/humrep/deaa317.
7
Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers.真正的复发性着床失败率较低：连续三次冷冻整倍体单胚胎移植的结果。
Fertil Steril. 2021 Jan;115(1):45-53. doi: 10.1016/j.fertnstert.2020.07.002. Epub 2020 Oct 16.
8
Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure.评估子宫内膜容受性检测和胚胎植入前非整倍体基因检测在克服反复种植失败中的作用。
J Assist Reprod Genet. 2020 Dec;37(12):2989-2997. doi: 10.1007/s10815-020-01948-7. Epub 2020 Sep 24.
9
A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy.一项多中心、前瞻性、盲法、非选择性研究，评估了使用靶向下一代测序的胚胎植入前遗传学检测非整倍体分析进行非整倍体诊断的预测价值以及活检的影响。
Fertil Steril. 2021 Mar;115(3):627-637. doi: 10.1016/j.fertnstert.2020.07.052. Epub 2020 Aug 28.
10
A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF.一项比较个体化、冷冻和新鲜囊胚移植在体外受精中应用的 5 年多中心随机对照试验。
Reprod Biomed Online. 2020 Sep;41(3):402-415. doi: 10.1016/j.rbmo.2020.06.002. Epub 2020 Jun 15.
Zotero 插件