Department of Pharmacology, Faculty of Pharmaceutical Science, Government College University, Faisalabad, Pakistan.
Institutes of Physiology, and Pharmacology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
Pak J Pharm Sci. 2021 Sep;34(5(Supplementary)):1929-1937.
The Vitis vinifera (VV) and Zingiber zerumbet (ZZ) are popular functional foods which are used for the treatment of cardiovascular ailments. These possess antiproliferative, antiplatelet and antioxidant effects. The current study has been designed to ascertain their effectiveness against Isoproterenol (ISO)-induced myocardial infarction (MI). Chronic administration of VV and ZZ was accessed for its cardio-protective effect in ISO-induced MI rats. Male albino rats were treated with VV (250 mg/kg, p.o.), ZZ (200 mg/kg, p.o.) and its combination (Vitis vinifera + Zingiber zerumbet) VZ for 30 days prior to ISO administration (85 mg/kg, S/C). Electrocardiography (ECG) and Blood Pressure (BP) were measured using PowerLab data acquisition system. Biochemical serum markers, tissue histopathology and HPLC finger printing were performed. The VV, ZZ and its combination VZ showed significant protective effects on ST segment elevation, cardiac biomarkers; Troponin I (Trop I), creatine kinase-MB (CK-MB), alanine transaminase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH), enhanced the cardiac antioxidant defense system, restored the hematological (WBCs, RBCs, Platelets) & coagulation parameters and improved the lipid profile and histopathological alterations such as tissue necrosis, infiltration and edema which were observed only in ISO administered rats. These results indicate that V. vinifera and Z. zerumbet possess cardio protective effects possibly mediated through maintenance of endogenous antioxidant levels, cardiac biomarkers and lipid parameters.
葡萄（VV）和姜黄（ZZ）是受欢迎的功能食品，用于治疗心血管疾病。它们具有抗增殖、抗血小板和抗氧化作用。本研究旨在确定它们对异丙肾上腺素（ISO）诱导的心肌梗死（MI）的疗效。评估了慢性给予 VV 和 ZZ 对 ISO 诱导的 MI 大鼠的心脏保护作用。雄性白化大鼠在 ISO 给药（85mg/kg，S/C）前 30 天用 VV（250mg/kg，po）、ZZ（200mg/kg，po）及其组合（葡萄+姜黄）VZ 治疗。使用 PowerLab 数据采集系统测量心电图（ECG）和血压（BP）。进行了生化血清标志物、组织病理学和 HPLC 指纹图谱分析。VV、ZZ 及其组合 VZ 对 ST 段抬高、心脏生物标志物（肌钙蛋白 I（Trop I）、肌酸激酶-MB（CK-MB）、丙氨酸转氨酶（ALT）、天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH））有显著的保护作用，增强了心脏抗氧化防御系统，恢复了血液学（白细胞计数、红细胞计数、血小板）和凝血参数，并改善了脂质谱和组织病理学改变，如仅在 ISO 给药大鼠中观察到的组织坏死、浸润和水肿。这些结果表明，葡萄和姜黄具有心脏保护作用，可能是通过维持内源性抗氧化水平、心脏生物标志物和脂质参数来介导的。
