Department of Urology, Faculty of Medicine, University of Freiburg - Medical Centre, Freiburg, Germany.
Department of Urology, University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
Andrologia. 2022 Apr;54(3):e14332. doi: 10.1111/and.14332. Epub 2021 Nov 26.
Prostate cancer can be detected incidentally after surgical therapy for benign prostatic obstruction such as holmium laser enucleation of the prostate (HoLEP), thus called incidental prostate cancer (iPCa). We aimed to review the studies on iPCa detected after HoLEP and investigate its prevalence. A detailed search of original articles was conducted via the PubMed-MEDLINE, Web of Science, Wiley Online Library and Cochrane Library databases in the last 10 years up to 1 May 2021 with the following search string solely or in combination: "prostate cancer", "prostate carcinoma", "holmium laser enucleation of the prostate" and "HoLEP". We identified 19 articles to include in our analysis and divided them into six main categories: HoLEP versus open prostatectomy and/or transurethral resection of the prostate in terms of iPCa, oncological and functional outcomes, the role of imaging modalities in detecting iPCa, predictive factors of iPCa, the role of prostate-specific antigen kinetics in detecting iPCa and the management of iPCa after HoLEP. We found that the iPCa after HoLEP rate ranges from 5.64% to 23.3%. Functional and oncological outcomes were reported to be encouraging. Oncological treatment options are available in a wide range.
前列腺癌可在良性前列腺梗阻的手术治疗后偶然发现，例如钬激光前列腺剜除术（HoLEP），因此称为偶发前列腺癌（iPCa）。我们旨在回顾 HoLEP 后检测到的 iPCa 的研究，并调查其患病率。在过去 10 年中，我们仅使用或组合使用以下搜索字符串，通过 PubMed-MEDLINE、Web of Science、Wiley Online Library 和 Cochrane Library 数据库对原始文章进行了详细搜索，截止日期为 2021 年 5 月 1 日：“前列腺癌”、“前列腺癌”、“钬激光前列腺剜除术”和“HoLEP”。我们确定了 19 篇文章纳入我们的分析，并将它们分为六个主要类别：HoLEP 与开放性前列腺切除术和/或经尿道前列腺切除术在 iPCa、肿瘤学和功能结果方面的比较、影像学在检测 iPCa 中的作用、iPCa 的预测因素、前列腺特异性抗原动力学在检测 iPCa 中的作用以及 HoLEP 后 iPCa 的管理。我们发现 HoLEP 后 iPCa 的发生率范围为 5.64%至 23.3%。报告的功能和肿瘤学结果令人鼓舞。有多种广泛的肿瘤学治疗选择。
