Rusz Jan, Janzen Annette, Tykalová Tereza, Novotný Michal, Zogala David, Timmermann Lars, Růžička Evžen, Šonka Karel, Dušek Petr, Oertel Wolfgang
Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Mov Disord. 2022 Mar;37(3):619-623. doi: 10.1002/mds.28873. Epub 2021 Nov 26.
Impairments of olfactory and speech function are likely early prodromal symptoms of α-synucleinopathy.
The aim of this study is to assess whether dysprosody is present in isolated rapid eye movement sleep behavior disorder (iRBD) with hyposmia/anosmia and a normal nigrostriatal system.
Pitch variability during speech was investigated in 17 iRBD subjects with normal olfactory function (iRBD-NOF), 30 iRBD subjects with abnormal olfactory function (iRBD-AOF), and 50 healthy controls. iRBD subjects were evaluated using the University of Pennsylvania Smell Identification Test and [123I]-2ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane dopamine transporter single-photon emission computed tomography (DAT-SPECT). All iRBD subjects completed the 24-month follow-up with DAT-SPECT, speech, and olfactory testing.
At baseline, only iRBD-AOF showed monopitch when compared to iRBD-NOF (P = 0.04) and controls (P = 0.03), with no difference between iRBD-NOF and controls (P = 1). At follow-up, dysprosody progressed only in iRBD-AOF with abnormal DAT-SPECT (P = 0.03).
Prosody is impaired in hyposmic but not in normosmic iRBD subjects before the nigrostriatal dopaminergic transmission is affected (Braak stage 2). © 2021 International Parkinson and Movement Disorder Society.
嗅觉和言语功能障碍可能是α-突触核蛋白病的早期前驱症状。
本研究旨在评估嗅觉减退/嗅觉丧失且黑质纹状体系统正常的孤立性快速眼动睡眠行为障碍（iRBD）患者是否存在韵律障碍。
对17名嗅觉功能正常的iRBD患者（iRBD-NOF）、30名嗅觉功能异常的iRBD患者（iRBD-AOF）和50名健康对照者进行言语过程中的音高变异性研究。使用宾夕法尼亚大学嗅觉识别测试和[123I]-2β-甲氧基羰基-3β-（4-碘苯基）-N-（3-氟丙基）-去甲托烷多巴胺转运体单光子发射计算机断层扫描（DAT-SPECT）对iRBD患者进行评估。所有iRBD患者均完成了为期24个月的DAT-SPECT、言语和嗅觉测试随访。
在基线时，与iRBD-NOF（P = 0.04）和对照组（P = 0.03）相比，仅iRBD-AOF表现出单音调，iRBD-NOF与对照组之间无差异（P = 1）。在随访中，韵律障碍仅在DAT-SPECT异常的iRBD-AOF中进展（P = 0.03）。
在黑质纹状体多巴胺能传递受到影响之前（Braak 2期），嗅觉减退的iRBD患者存在韵律障碍，而嗅觉正常的iRBD患者则不存在。© 2021国际帕金森病和运动障碍协会。
