State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, P. R. China.
Chem Biodivers. 2022 Jan;19(1):e202100868. doi: 10.1002/cbdv.202100868. Epub 2021 Dec 22.
Two new seco-prezizaane-type sesquiterpenes, 2β-hydroxy-6-deoxyneoanisatin (1) and 3,4-anhydro-2-oxo-1α-hydroxy-6-deoxyneoanisatin (2), and two new prenylated C -C compounds, illilanceofunones A (3) and B (4), were obtained from the fruits of Illicium lanceolatum, along with four known prenylated C -C compounds (5-8). Their structures were proposed through HR-ESI-MS, H, C, and 2D NMR data interpretation. Moreover, the absolute configuration of 1 and 2 were further assigned by single-crystal X-ray diffraction analysis and electronic circular dichroism (ECD) calculations, respectively. Illihenryipyranol A (6) exhibited neuroprotective activity against MPP -induced PC12 cell damage in a dose-dependent manner.
从八角属植物Illicium lanceolatum 的果实中分离得到了两个新的倍半萜类化合物，2β-羟基-6-去氧新八角亭（1）和 3,4-脱水-2-氧代-1α-羟基-6-去氧新八角亭（2），以及两个新的prenylated C-C 化合物，illiilanceofunones A（3）和 B（4）。通过高分辨电喷雾电离质谱（HR-ESI-MS）、1 H NMR、13 C NMR 和二维 NMR 数据解析，提出了它们的结构。此外，通过单晶 X 射线衍射分析和电子圆二色谱（ECD）计算，分别进一步确定了 1 和 2 的绝对构型。Illihenryipyranol A（6）对 MPP+-诱导的 PC12 细胞损伤具有剂量依赖性的神经保护活性。
