Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
CNS Neurosci Ther. 2022 Feb;28(2):269-278. doi: 10.1111/cns.13767. Epub 2021 Nov 26.
To identify the metabolic pattern and prognostic predictors in anti-gamma-aminobutyric-acid B (GABAB) receptor encephalitis using F-fluorodeoxy-glucose positron emission tomography ( F-FDG-PET).
Twenty-one patients diagnosed anti-GABAB receptor encephalitis who underwent F-FDG-PET at first hospitalization were retrospectively reviewed. F-FDG-PET images were analyzed in comparison with controls. Further group comparisons of F-FDG-PET data were carried out between prognostic subgroups.
F-FDG-PET was abnormal in 81% patients with anti-GABAB receptor encephalitis and was more sensitive than MRI (81% vs. 42.9%, p = 0.025). Alter limbic lobe glucose metabolism (mostly hypermetabolism) was observed in 14 patients (66.7%), of whom 10 (10/14, 71.4%) demonstrated hypermetabolism in the medial temporal lobe (MTL). Group analysis also confirmed MTL hypermetabolism in association with relative frontal and parietal hypometabolism was a general metabolic pattern. After a median follow-up of 33 months, the group comparisons revealed that patients with poor outcome demonstrated increased metabolism in the MTL compared to those with good outcome.
F-FDG-PET may be more sensitive than MRI in the early diagnosis of anti-GABAB receptor encephalitis. MTL hypermetabolism was associated with relative frontal or parietal hypometabolism and may serve as a prognostic biomarker in anti-GABAB receptor encephalitis.
使用 F-氟代脱氧葡萄糖正电子发射断层扫描（ F-FDG-PET）来确定抗γ-氨基丁酸 B（GABAB）受体脑炎的代谢模式和预后预测因子。
回顾性分析了 21 例首次住院时接受 F-FDG-PET 的抗 GABAB 受体脑炎患者。将 F-FDG-PET 图像与对照组进行比较分析。进一步对预后亚组之间的 F-FDG-PET 数据进行了组间比较。
抗 GABAB 受体脑炎患者中有 81%的患者 F-FDG-PET 异常，比 MRI 更敏感（81%比 42.9%，p=0.025）。14 名患者（66.7%）出现边缘叶葡萄糖代谢改变（主要为高代谢），其中 10 名患者（10/14，71.4%）表现为内侧颞叶（MTL）高代谢。组间分析还证实，MTL 高代谢与相对额区和顶区代谢低下是一种普遍的代谢模式。中位随访 33 个月后，组间比较显示，预后不良组的 MTL 代谢较预后良好组增加。
F-FDG-PET 可能比 MRI 更敏感，有助于早期诊断抗 GABAB 受体脑炎。MTL 高代谢与相对额区或顶区代谢低下相关，可能作为抗 GABAB 受体脑炎的预后生物标志物。
