Kitware, Inc. Medical Computing Group, Carrboro, NC, USA.
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Int J Comput Assist Radiol Surg. 2022 Feb;17(2):403-411. doi: 10.1007/s11548-021-02524-9. Epub 2021 Nov 27.
Surgery for nasal airway obstruction (NAO) has a high failure rate, with up to 50% of patients reporting persistent symptoms postoperatively. Virtual surgery planning has the potential to improve surgical outcomes, but current manual methods are too labor-intensive to be adopted on a large scale. This manuscript introduces an automatic atlas-based approach for performing virtual septoplasties.
A cohort of 47 healthy subjects and 26 NAO patients was investigated. An atlas of healthy nasal geometry was constructed. The automatic virtual septoplasty method consists of a multi-stage registration approach to fit the atlas to a target NAO patient, automatically segment the patient's septum and airway, and deform the patient image to have a non-deviated septum.
Our automatic virtual septoplasty method straightened the septum successfully in 18 out of 26 NAO patients (69% of cases). In these cases, the ratio of the higher to the lower airspace cross-sectional areas in the left and right nasal cavities improved from 1.47 ± 0.45 to 1.16 ± 0.33 in the region surrounding the septal deviation, showing that the nasal airway became more symmetric after virtual septoplasty.
This automated virtual septoplasty technique has the potential to greatly reduce the effort required to perform computational fluid dynamics (CFD) analysis of nasal airflow for NAO surgical planning. Future studies are needed to investigate if virtual surgery planning using this method is predictive of subjective symptoms in NAO patients after septoplasty.
鼻腔气道阻塞(NAO)的手术成功率较高,但高达 50%的患者术后仍存在持续症状。虚拟手术规划有可能改善手术效果,但目前手动方法过于繁琐,无法大规模采用。本文介绍了一种基于自动图谱的行虚拟鼻中隔成形术的方法。
对 47 名健康受试者和 26 名 NAO 患者进行了研究。构建了一个健康鼻几何图谱。自动虚拟鼻中隔成形术方法包括多阶段配准方法,将图谱配准到目标 NAO 患者,自动分割患者鼻中隔和气道,并对患者图像进行变形以获得非偏斜鼻中隔。
我们的自动虚拟鼻中隔成形术方法成功地使 26 名 NAO 患者中的 18 名(69%的病例)鼻中隔变直。在这些病例中,鼻中隔偏曲区域左右鼻腔的上、下气道截面积比从 1.47±0.45 提高到 1.16±0.33,表明虚拟鼻中隔成形术后鼻腔气道变得更加对称。
这种自动化虚拟鼻中隔成形术技术有可能大大减少为 NAO 手术规划进行计算流体动力学(CFD)分析所需的工作量。未来的研究需要调查使用该方法进行虚拟手术规划是否可以预测 NAO 患者鼻中隔成形术后的主观症状。