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虚拟鼻中隔成形术:一种预测鼻腔气道阻塞患者手术效果的方法。

Virtual septoplasty: a method to predict surgical outcomes for patients with nasal airway obstruction.

机构信息

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.

Joint Department of Biomedical Engineering, Marquette University and The Medical College of Wisconsin, Milwaukee, WI, USA.

出版信息

Int J Comput Assist Radiol Surg. 2020 Apr;15(4):725-735. doi: 10.1007/s11548-020-02124-z. Epub 2020 Feb 20.

Abstract

PURPOSE

A deviated nasal septum is the most common etiology for nasal airway obstruction (NAO), and septoplasty is the most common surgical procedure performed by ear-nose-throat surgeons in adults. However, quantitative criteria are rarely adopted to select patients for surgery, which may explain why up to 50% of patients report persistent or recurrent symptoms of nasal obstruction postoperatively. This study reports a systematic virtual surgery method to identify patients who may benefit from septoplasty.

METHODS

One patient with symptoms of NAO due to a septal deviation was selected to illustrate the virtual surgery concept. Virtual septoplasty was implemented in three steps: (1) determining if septal geometry is abnormal preoperatively, (2) virtually correcting the deviation while preserving the anatomical shape of the septum, and (3) estimating the post-surgical improvement in airflow using computational fluid dynamics. Anatomical and functional changes predicted by the virtual surgery method were compared to a standard septoplasty performed independently from the computational analysis.

RESULTS

A benchmark healthy nasal septum geometry was obtained by averaging the septum dimensions of 47 healthy individuals. A comparison of the nasal septum geometry in the NAO patient with the benchmark geometry identified the precise locations where septal deviation and thickness exceeded the healthy range. Good agreement was found between the virtual surgery predictions and the actual surgical outcomes for both airspace minimal cross-sectional area (0.05 cm pre-surgery, 0.54 cm virtual surgery, 0.50 cm actual surgery) and nasal resistance (0.91 Pa.s/ml pre-surgery, 0.08 Pa.s/ml virtual surgery, 0.08 Pa.s/ml actual surgery).

CONCLUSIONS

Previous virtual surgery methods for NAO were based on manual edits and subjective criteria. The virtual septoplasty method proposed in this study is objective and has the potential to be fully automated. Future implementation of this method in virtual surgery planning software has the potential to improve septoplasty outcomes.

摘要

目的

鼻中隔偏曲是导致鼻腔气道阻塞(NAO)的最常见病因,鼻中隔成形术是耳鼻喉科医生在成人中最常进行的手术。然而,很少采用定量标准来选择手术患者,这可能解释了为什么多达 50%的患者在手术后报告持续或复发的鼻塞症状。本研究报告了一种系统的虚拟手术方法,以确定可能受益于鼻中隔成形术的患者。

方法

选择一名因鼻中隔偏曲而出现 NAO 症状的患者来说明虚拟手术概念。虚拟鼻中隔成形术分三步实施:(1)术前确定鼻中隔几何形状是否异常,(2)在保留鼻中隔解剖形状的同时虚拟纠正偏曲,(3)使用计算流体动力学估计手术后气流的改善。将虚拟手术方法预测的解剖和功能变化与独立于计算分析进行的标准鼻中隔成形术进行比较。

结果

通过对 47 名健康个体鼻中隔尺寸的平均化,获得了基准健康鼻中隔几何形状。将 NAO 患者的鼻中隔几何形状与基准几何形状进行比较,确定了鼻中隔偏曲和厚度超出健康范围的确切位置。虚拟手术预测与实际手术结果之间存在良好的一致性,包括气道最小横截面积(术前 0.05cm,虚拟手术 0.54cm,实际手术 0.50cm)和鼻腔阻力(术前 0.91Pa.s/ml,虚拟手术 0.08Pa.s/ml,实际手术 0.08Pa.s/ml)。

结论

以前的 NAO 虚拟手术方法基于手动编辑和主观标准。本研究提出的虚拟鼻中隔成形术方法是客观的,并且具有完全自动化的潜力。未来在虚拟手术规划软件中实施这种方法有可能改善鼻中隔成形术的结果。

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本文引用的文献

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Normative ranges of nasal airflow variables in healthy adults.健康成年人鼻气流变量的参考范围。
Int J Comput Assist Radiol Surg. 2020 Jan;15(1):87-98. doi: 10.1007/s11548-019-02023-y. Epub 2019 Jul 2.
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Nasal surgery handled by CFD tools.鼻外科手术由 CFD 工具处理。
Int J Numer Method Biomed Eng. 2018 Oct;34(10):e3126. doi: 10.1002/cnm.3126. Epub 2018 Jul 24.
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DigBody: A new 3D modeling tool for nasal virtual surgery.DigBody:一种用于鼻虚拟手术的新型 3D 建模工具。
Comput Biol Med. 2018 Jul 1;98:118-125. doi: 10.1016/j.compbiomed.2018.05.016. Epub 2018 May 16.

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