MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, UK.
MRC Laboratory of Molecular Biology, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, UK.
Curr Opin Neurobiol. 2021 Dec;71:139-149. doi: 10.1016/j.conb.2021.10.006. Epub 2021 Nov 24.
Since the Cambrian, animals diversified from a few body forms or bauplans, into many extinct and all extant species. A characteristic neural architecture serves each bauplan. How the connectome of each animal differs from that of closely related species or whether it converged into an optimal architecture shared with more distant ones is unknown. Recent technological innovations in molecular biology, microscopy, digital data storage and processing, and computational neuroscience have lowered the barriers for whole-brain connectomics. Comparative connectomics of suitable, relatively small, representative species across the phylogenetic tree can infer the archetypal neural architecture of each bauplan and identify any circuits that possibly converged onto a shared and potentially optimal, structure.
自寒武纪以来，动物从少数几种体型或形态发生了多样化，形成了许多已灭绝和现存的物种。每种形态都有其独特的神经结构。每个动物的连接组与亲缘关系较近的物种有何不同，或者是否趋同于与更远缘的物种共享的最佳结构尚不清楚。近年来，分子生物学、显微镜技术、数字数据存储和处理以及计算神经科学方面的技术创新降低了全脑连接组学的门槛。在系统发育树上对适合的、相对较小的、具有代表性的物种进行比较连接组学研究，可以推断出每种形态的典型神经结构，并确定任何可能趋同于共享和潜在最佳结构的回路。
