CD133 作为卵巢癌发生的重要标志物。
CD133 Act as an Essential Marker in Ovarian Carcinogenesis.
机构信息
Department of Anatomical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
Department of Histology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar, Indonesia.
出版信息
Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3525-3531. doi: 10.31557/APJCP.2021.22.11.3525.
OBJECTIVE
To analyze the role of cancer stem cells (CSC) in ovarian carcinogenesis through the identification of CD133 expression in the normal ovary (NO), serous cystadenoma (SC), borderline serous tumour (BST), low-grade serous carcinoma (LGSC), and high-grade serous carcinoma (HGSC).
MATERIALS AND METHODS
A total of 48 tissue samples contain 5 NO, 10 SC, 5 BST, 8 LGSC, and 20 HGSC were stained with anti-CD133 antibody by immunohistochemical protocol. The difference in the H-score of CD133 expression between groups and their relationship to age, histomorphology, and localization was analyzed.
RESULTS
CD133 expression varied among tumor groups, with clinicopathologic parameters showing diverse associations (age p = 0.773; histomorphology p = 0.001; and localization p = 0.026). The comparison of CD133 H-scores differed significantly between each group (p = 0.0031), in which precursor and malignant lesions possessed more robust CD133 expression.
CONCLUSION
The presence of CD133 cellular expression and localization in different types of serous ovarian tumours suggests that these markers are involved in ovarian tumorigenesis.
目的
通过鉴定卵巢正常组织（NO）、浆液性囊腺瘤（SC）、交界性浆液性肿瘤（BST）、低级别浆液性癌（LGSC）和高级别浆液性癌（HGSC）中 CD133 的表达，分析癌症干细胞（CSC）在卵巢发生中的作用。
材料与方法
共对 48 份组织样本进行了分析，其中包括 5 份 NO、10 份 SC、5 份 BST、8 份 LGSC 和 20 份 HGSC，通过免疫组织化学方案用抗 CD133 抗体对其进行染色。分析了各组间 CD133 表达的 H 评分差异及其与年龄、组织形态学和定位的关系。
结果
CD133 的表达在肿瘤组之间存在差异，临床病理参数的相关性也各不相同（年龄 p=0.773；组织形态学 p=0.001；定位 p=0.026）。各组间 CD133 H 评分的比较差异有统计学意义（p=0.0031），其中前体和恶性病变具有更强的 CD133 表达。
结论
不同类型浆液性卵巢肿瘤中 CD133 细胞表达和定位的存在提示这些标志物参与了卵巢肿瘤的发生。
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