Kodde Andrea, Mischke Mona, Rakhshandehroo Maryam, Voggel Jenny, Fink Gregor, Nüsken Eva, Rauh Manfred, van der Beek Eline M, Dötsch Jörg, Nüsken Kai-Dietrich
Danone Nutricia Research, Utrecht, The Netherlands.
Department of Pediatrics and Adolescent Medicine, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany.
Nutr Metab (Lond). 2021 Nov 27;18(1):101. doi: 10.1186/s12986-021-00614-8.
Being born small-for-gestational-age, especially with subsequent catch-up growth, is associated with impaired metabolic health in later-life. We previously showed that a postnatal diet with an adapted lipid droplet structure can ameliorate some of the adverse metabolic consequences in intrauterine growth-restricted (IUGR) rats. The aim of the present work was to explore possible underlying mechanism(s) and potential biomarkers. To this end, serum metabolomics was performed in postnatal day (PN) 42 and PN96 samples of the above-mentioned rat offspring, born after uterine vasculature ligation. Blood samples were collected at PN42, directly after a postnatal dietary intervention with either complex lipid matrix (CLM) or control (CTRL) diet, and at PN96 after a subsequent western-style diet (WSD). Offspring of Non-operated (NOP) dams fed CTRL in early life were included as control group. In the PN42 metabolomics data, 11 co-abundance modules of metabolites were identified, of which four were significantly correlated to adult blood glucose levels at PN96. Further analyses showed that Lysophosphatidylcholine(18:2) (LysoPC(18:2)) levels were reduced by ligation (p < 0.01) and restored in CLM fed animals (p < 0.05). LysoPC(18:2) levels at PN42 correlated inversely with adult blood glucose levels. These data indicate that early-life LysoPC(18:2) blood levels may predict adult blood glucose levels and are affected by a postnatal diet with an adapted lipid droplet structure in IUGR offspring.
出生时小于胎龄，尤其是随后出现追赶性生长，与晚年代谢健康受损有关。我们之前表明，具有适应性脂滴结构的产后饮食可以改善宫内生长受限（IUGR）大鼠的一些不良代谢后果。本研究的目的是探索可能的潜在机制和潜在生物标志物。为此，对上述子宫血管结扎后出生的大鼠后代出生后第42天（PN42）和第96天（PN96）的样本进行了血清代谢组学分析。在PN42时，在给予复合脂质基质（CLM）或对照（CTRL）饮食的产后饮食干预后直接采集血样，在PN96时，在随后给予西式饮食（WSD）后采集血样。将早年喂养CTRL的未手术（NOP）母鼠的后代作为对照组。在PN42代谢组学数据中，鉴定出11个代谢物共丰度模块，其中4个与PN96时的成年血糖水平显著相关。进一步分析表明，结扎可降低溶血磷脂酰胆碱（18:2）（LysoPC(18:2)）水平（p < 0.01），而在CLM喂养的动物中恢复（p < 0.05）。PN42时的LysoPC(18:2)水平与成年血糖水平呈负相关。这些数据表明，生命早期的LysoPC(18:2)血液水平可能预测成年血糖水平，并受到IUGR后代中具有适应性脂滴结构的产后饮食的影响。
