Center for Regenerative Medicine, Institute for Translational Medicine, Qingdao University, Qingdao, China.
Departments of Pharmacology and Therapeutics, Biochemistry and Medical Genetics, Center for Research and Treatment of Atherosclerosis, DREAM Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
J Cell Mol Med. 2019 Feb;23(2):702-710. doi: 10.1111/jcmm.13984. Epub 2018 Nov 6.
Insulin resistance induced by high-fat diet and impropriate life style is a major contributor to the pathogenesis of metabolic disease. However, the underlying molecular mechanisms remain unclear. Recent studies in metabolic dysfunction have extended this beyond simply elevated cholesterol and triglycerides levels and have identified a key role for lipid metabolism. For example, altered phospholipid metabolism has now become central in the pathogenesis of metabolic disease. In this review, we discuss the association between insulin sensitivity and phospholipid metabolism and highlight the most significant discoveries generated over the last several decades. Finally, we summarize the current knowledge surrounding the molecular mechanisms related to phospholipids and insulin resistance and provide new insight for future research into their relationship.
由高脂肪饮食和不当生活方式引起的胰岛素抵抗是代谢性疾病发病机制的主要原因。然而，其潜在的分子机制尚不清楚。最近关于代谢功能障碍的研究已经超出了胆固醇和甘油三酯水平升高的简单范畴，并确定了脂质代谢的关键作用。例如，磷脂代谢的改变现在已成为代谢性疾病发病机制的核心。在这篇综述中，我们讨论了胰岛素敏感性与磷脂代谢之间的关系，并强调了过去几十年产生的最重要发现。最后，我们总结了与磷脂和胰岛素抵抗相关的分子机制的现有知识，并为它们之间关系的未来研究提供了新的见解。
