Department of Materials Science and Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Department of Pathology, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do 15355, Republic of Korea.
Colloids Surf B Biointerfaces. 2022 Feb;210:112223. doi: 10.1016/j.colsurfb.2021.112223. Epub 2021 Nov 16.
Silicone-based fillers have been applied in several branches of medicine, such as soft tissue augmentation, because of their stability and durability. However, the inherently hydrophobic surfaces of silicone occasionally cause excessive deposition of the fibrous matrix in vivo, leading to severe fibrosis. In this study, we evaluated the use of a zwitterionic copolymer to offer a facile surface treatment method for silicone-based fillers and performed a preclinical trial of the formulation as-prepared. The copolymer has amphiphilic moieties, which act as macromolecular surfactants that can functionalize and stabilize the silicone particles during fabrication. The effectiveness and safety of the particle filler were evaluated histologically by scoring the peri-implant tissues into previously defined categories. Our results suggest that zwitterion-coated silicone fillers can inhibit protein adsorption, and thus, help attenuate foreign body reactions in a rat model. This demonstrates their potential for wide application in different fields within the discipline of medicine.
基于硅酮的填充物由于其稳定性和耐久性，已被应用于医学的多个领域，如软组织填充。然而，硅酮固有的疏水性表面偶尔会导致体内纤维基质的过度沉积，从而导致严重的纤维化。在这项研究中，我们评估了使用两性离子共聚物为硅酮基填充物提供一种简便的表面处理方法，并对所制备的配方进行了临床前试验。该共聚物具有双亲基团，可作为大分子表面活性剂，在制造过程中对硅酮颗粒进行功能化和稳定。通过将植入物周围组织按先前定义的类别进行评分，评估颗粒填充物的有效性和安全性。我们的结果表明，两性离子涂层的硅酮填充剂可以抑制蛋白质的吸附，从而有助于减轻大鼠模型中的异物反应。这表明它们有可能在医学领域的不同领域得到广泛应用。
