Li Li, Gao Bu-Lang, Wu Qiao-Wei, Shao Qiu-Ji, Wang Zi-Liang, Zhang Kun, Li Tian-Xiao
Henan Provincial People's Hospital, Zhengzhou University, 7 Weiwu Road, Zhengzhou, Henan Province 450000, China.
Henan Provincial People's Hospital, Zhengzhou University, 7 Weiwu Road, Zhengzhou, Henan Province 450000, China.
J Clin Neurosci. 2022 Feb;96:127-132. doi: 10.1016/j.jocn.2021.11.006. Epub 2021 Nov 24.
To investigate the safety and effect of the Pipeline Embolization Device (PED) Flex device in the treatment of large unruptured posterior circulation aneurysms in a single center.
Patients with large unruptured posterior circulation aneurysms which were treated with the PED Flex device were enrolled. The clinical, endovascular and follow-up data were analyzed, and the O'Kelly-Marotta (OKM) grading system was used to assess the aneurysm occlusion status.
Fourteen patients with 14 large posterior circulation aneurysms who were treated with the PED Flex device were enrolled. The maximal diameter of aneurysm was 17.0 ± 3.9 mm. Fourteen PED Flex devices were deployed in 14 patients, with a technical success rate of 100%. All stents covered the aneurysm neck with good wall adherence and patent parent artery. Ten (71.4%) aneurysms were treated with a single PED Flex device each, and four (28.6%) patients experienced additional coiling. No neurological complications occurred in the periprocedural period. The mRS was 0 in eleven (78.6%) patients, 1 in two (14.3%), and 2 in one (7.1%) at discharge. All patients were followed up at 6-28 months (median 18), with an mRS score of 0 in all patients. Twelve (85.7%) patients experienced digital subtraction angiography 6-28 (median 18) months after the embolization procedure, and the OKM grade was D in nine (75%), C in two (16.7%), and B in one (8.3%).
The Pipeline Flex Embolization Device can be safely applied to treat large unruptured posterior circulation aneurysms with a high complete aneurysm occlusion rate at follow-up.
在单中心研究Pipeline栓塞装置（PED）Flex装置治疗大型未破裂后循环动脉瘤的安全性和疗效。
纳入采用PED Flex装置治疗的大型未破裂后循环动脉瘤患者。分析临床、血管内治疗及随访数据，并采用奥凯利-马罗塔（OKM）分级系统评估动脉瘤闭塞情况。
纳入14例采用PED Flex装置治疗的14个大型后循环动脉瘤患者。动脉瘤最大直径为17.0 ± 3.9毫米。14例患者共植入14枚PED Flex装置，技术成功率为100%。所有支架均覆盖动脉瘤颈部，贴壁良好，载瘤动脉通畅。10个（71.4%）动脉瘤各用1枚PED Flex装置治疗，4例（28.6%）患者进行了额外的弹簧圈栓塞。围手术期未发生神经并发症。出院时，11例（78.6%）患者改良Rankin量表（mRS）评分为0，2例（14.3%）为1，1例（7.1%）为2。所有患者均随访6 - 28个月（中位时间18个月），所有患者mRS评分均为0。12例（85.7%）患者在栓塞术后6 - 28个月（中位时间18个月）接受了数字减影血管造影，OKM分级为D级的有9例（75%），C级2例（16.7%），B级1例（8.3%）。
Pipeline Flex栓塞装置可安全用于治疗大型未破裂后循环动脉瘤，随访时动脉瘤完全闭塞率高。
