Xuexian Zhang, Xuerou Meng, Yuanjin Ma, Bin Xiong, Wenqiu Pan, Wei Zhao, Ruidong Wang
Department of Interventional Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Intervention, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Front Neurol. 2025 Mar 14;16:1535044. doi: 10.3389/fneur.2025.1535044. eCollection 2025.
Flow diverters (FDs) are widely used in the treatment of intracranial aneurysms (IAs). The Lattice flow diverter (LFD) is a novel FD developed in China, specifically designed for large or giant IAs. Currently, few studies have compared various FDs in the treatment of these conditions. This study endeavors to contrast the safety and efficacy of the Pipeline Flex embolization device (PED Flex) and LFD in the treatment of unruptured intracranial aneurysms (UIAs).
This study retrospectively reviewed cases of UIAs managed with PED Flex or LFD at the Department of Interventional Radiology, Kunming Medical University's First Affiliated Hospital from March 2022 to September 2024. We analyzed demographic characteristics, aneurysm features, medical history, complications, aneurysm occlusion, and clinical outcomes.
The study cohort consisted of 99 patients with 99 aneurysms, including 48 treated with PED Flex and 51 with LFD. The median follow-up duration was 9 months for both groups. Rates of complete aneurysm occlusion (81.3% vs. 78.4%, = 0.727), successful aneurysm occlusion (87.5% vs. 86.3%, = 0.857), and complication rates (2.1% vs. 3.9%, = 0.727) did not differ significantly between the groups. Similarly, rates of in-stent stenosis (ISS) (14.6% vs. 11.8%, = 0.678) and positive clinical outcomes were comparable.
Our preliminary findings indicate that compared with PED Flex, the new domestic LFD has similar safety and effectiveness in treating UIAs. It is a new option for treating intracranial aneurysms and may have broad application prospects.
血流导向装置（FDs）广泛应用于颅内动脉瘤（IAs）的治疗。密网支架血流导向装置（LFD）是我国研发的一种新型血流导向装置，专门用于治疗大型或巨大型颅内动脉瘤。目前，很少有研究比较不同血流导向装置在治疗这些疾病中的效果。本研究旨在对比Pipeline Flex栓塞装置（PED Flex）和密网支架血流导向装置（LFD）治疗未破裂颅内动脉瘤（UIAs）的安全性和有效性。
本研究回顾性分析了2022年3月至2024年9月在昆明医科大学第一附属医院介入放射科接受PED Flex或LFD治疗的未破裂颅内动脉瘤患者病例。我们分析了患者的人口统计学特征、动脉瘤特征、病史、并发症、动脉瘤闭塞情况及临床结局。
研究队列包括99例患者的99个动脉瘤，其中48例接受PED Flex治疗，51例接受LFD治疗。两组的中位随访时间均为9个月。两组间的完全动脉瘤闭塞率（81.3%对78.4%，P = 0.727）、成功动脉瘤闭塞率（87.5%对86.3%，P = 0.857）和并发症发生率（2.1%对3.9%，P = 0.727）差异均无统计学意义。同样，两组的支架内狭窄率（ISS）（14.6%对11.8%，P = 0.678）和良好临床结局率相当。
我们的初步研究结果表明，与PED Flex相比，国产新型密网支架血流导向装置（LFD）在治疗未破裂颅内动脉瘤方面具有相似的安全性和有效性。它是治疗颅内动脉瘤的一种新选择，可能具有广阔的应用前景。
