抗 N-甲基-D-天冬氨酸受体脑炎中失调的 CD40 和 CD40 配体表达。
Dysregulated CD40 and CD40 ligand expression in anti-N-methyl-d-aspartate receptor encephalitis.
机构信息
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China; Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
出版信息
J Neuroimmunol. 2022 Jan 15;362:577762. doi: 10.1016/j.jneuroim.2021.577762. Epub 2021 Nov 2.
Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.
抗 N-甲基-D-天冬氨酸受体脑炎（anti-NMDARE）是一种 B 细胞和抗体介导的自身免疫性疾病，可能受 CD40/CD40L 信号通路调节。我们招募了抗 NMDARE 患者，并测量了血清 CD40 和 CD40L 浓度。与健康对照组相比，抗 NMDARE 患者的血清 CD40 浓度降低，而 CD40L 浓度升高。抗 NMDARE 的急性期 CD40 和 CD40L 浓度均升高，缓解期则降低。血清 CD40L 水平与血清 CD40 水平呈正相关。这些结果表明，CD40/CD40L 信号通路可能参与抗 NMDARE 的发病机制。
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