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载有生物活性化合物的双乳液的稳定性和释放机制;批判性回顾。

Stability and release mechanisms of double emulsions loaded with bioactive compounds; a critical review.

机构信息

Department of Food Process Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Basij Square, Gorgan, Iran.

Department of Food Process Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Basij Square, Gorgan, Iran.

出版信息

Adv Colloid Interface Sci. 2022 Jan;299:102567. doi: 10.1016/j.cis.2021.102567. Epub 2021 Nov 22.

DOI:10.1016/j.cis.2021.102567
PMID:34839180
Abstract

Double emulsions (DEs), known as emulsions of emulsions, are dispersion systems in which the droplets of one dispersed liquid are further dispersed in another liquid, producing double-layered liquid droplets. These systems are widely used in the food and pharmaceutical industries due to their ability to co-encapsulate both hydrophilic and hydrophobic bioactive compounds. However, they are sensitive and unstable and their controlled release is challenging. In this study, first, the stability of DEs and their release mechanisms are reviewed. Then, the factors affecting their stability, and the release of bioactive compounds are studied. Finally, modeling of the release in DEs is discussed. This information can be useful to optimize the formulation of DEs in order to utilize them in different industries.

摘要

双乳液(DEs),也称为乳状液的乳液,是一种分散体系,其中一种分散液滴进一步分散在另一种液体中,形成双层液滴。由于能够共包封亲水性和疏水性生物活性化合物,这些系统在食品和制药行业中得到了广泛的应用。然而,它们是敏感和不稳定的,其控制释放具有挑战性。在本研究中,首先综述了 DEs 的稳定性及其释放机制。然后,研究了影响其稳定性和生物活性化合物释放的因素。最后,讨论了 DEs 中释放的建模。这些信息对于优化 DEs 的配方以在不同行业中利用它们可能是有用的。

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