Department of Obstetrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Department of Obstetrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Eur J Obstet Gynecol Reprod Biol. 2021 Dec;267:274-279. doi: 10.1016/j.ejogrb.2021.11.419. Epub 2021 Nov 18.
Invasive infection with group B streptococcus (GBS) can lead to intrauterine infection, and GBS can also spread via vertical transmission between mother and infant, resulting in adverse pregnancy outcomes. This study aimed to investigate the effects of GBS colonization in late gestation on vaginal micro-ecology, pregnancy outcomes and neonatal outcome.
One hundred and twenty pregnant women in the third trimester infected with GBS and 120 healthy counterparts who underwent a prenatal examination in the obstetrics department of the study hospital from June 2019 to December 2020 were selected for inclusion in the study. Vaginal micro-ecological index, mode of delivery, adverse pregnancy outcomes and neonatal Apgar score were compared between the two groups.
The incidence rates of vaginal micro-ecological disorders, intrauterine infection and neonatal infection were significantly higher in the GBS group compared with the control group. The incidence rates of neonatal fetal distress and pathological jaundice were much higher in the GBS group compared with the control group. The neonatal Apgar score was markedly lower in the GBS group compared with the control group.
GBS infection is correlated with the vaginal micro-environment. GBS colonization in late pregnancy has adverse effects on vaginal micro-ecology and pregnancy outcome.
B 族链球菌（GBS）感染可导致宫内感染，GBS 还可以通过母婴垂直传播进行传播，导致不良妊娠结局。本研究旨在探讨晚期妊娠 GBS 定植对阴道微生态、妊娠结局及新生儿结局的影响。
选取 2019 年 6 月至 2020 年 12 月在我院妇产科进行产前检查的 120 例感染 GBS 的孕晚期孕妇和 120 例健康对照者纳入本研究。比较两组阴道微生态指标、分娩方式、不良妊娠结局和新生儿 Apgar 评分。
GBS 组阴道微生态失调、宫内感染和新生儿感染的发生率明显高于对照组。GBS 组新生儿胎儿窘迫和病理性黄疸的发生率明显高于对照组。GBS 组新生儿 Apgar 评分明显低于对照组。
GBS 感染与阴道微环境有关。妊娠晚期 GBS 定植对阴道微生态和妊娠结局有不良影响。
