School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Clin Transl Oncol. 2022 May;24(5):757-769. doi: 10.1007/s12094-021-02734-2. Epub 2021 Nov 28.
Colorectal cancer (CRC) is one of the leading causes of mortality among cancers. Many aspects of this cancer are under investigation to find established markers of diagnosis, prognosis, and also potential drug targets. In this review article, we are going to discuss the possible solution to all these aims by investigating the literature about cancer-associated fibroblasts (CAFs) involved in CRC. Moreover, we are going to review their interaction with the tumor microenvironment (TME) and vitamin D and their role in tumorigenesis and metastasis. Moreover, we are going to expand more on some markers produced by them or related to them including FAP, a-SMA, CXCL12, TGF- β, POSTN, and β1-Integrin. Some signaling pathways related to CAFs are as follows: FAK, AKT, activin A, and YAP/TAZ. Some genes related to the CAFs which are found to be possible therapeutic targets include COL3A1, JAM3, AEBP1 and, CAF-derived TGFB3, WNT2, and WNT54.
结直肠癌（CRC）是癌症死亡的主要原因之一。为了找到诊断、预后的既定标志物，以及有潜力的药物靶点，人们对这种癌症的许多方面进行了研究。在这篇综述文章中，我们将通过研究癌症相关成纤维细胞（CAFs）在 CRC 中的作用来探讨实现这些目标的可能方法。此外，我们还将回顾它们与肿瘤微环境（TME）和维生素 D 的相互作用及其在肿瘤发生和转移中的作用。此外，我们将更详细地讨论它们产生的或与之相关的一些标志物，包括 FAP、α-SMA、CXCL12、TGF-β、POSTN 和 β1-整联蛋白。与 CAFs 相关的一些信号通路如下：FAK、AKT、激活素 A 和 YAP/TAZ。一些与 CAFs 相关的基因被发现可能是治疗靶点，包括 COL3A1、JAM3、AEBP1 和 CAF 衍生的 TGFB3、WNT2 和 WNT54。
