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双球囊阻断技术联合瘤腔内纤维蛋白黏合剂注射技术辅助下破裂腹主动脉瘤的血管腔内修复术

[Endovascular repair of ruptured abdominal aortic aneurysms assisted by double balloon occlusion technique combined with intra-aneurysm fibrin binder injection technique].

作者信息

Wei L C, Su Y M, Xu T F, Zheng Z Y, Zhang K, Luo C Z, Zheng Y, Wei X M, Ye Y H, Lan Y J, Wang Y F, Hou P Y

机构信息

Department of Vascular Surgery, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2021 Dec 1;59(12):987-993. doi: 10.3760/cma.j.cn112139-20210329-00146.

DOI:10.3760/cma.j.cn112139-20210329-00146
PMID:34839613
Abstract

To investigate the long-term efficacy and safety of alternating double balloon occlusion combined with intra-aneurysm injection of human fibrin binder in the endovascular repair of ruptured abdominal aortic aneurysm (rAAA). The clinical data of 28 patients with rAAA admitted to Department of Vascular Surgery, the Fourth Affiliated Hospital of Guangxi Medical University from January 2015 to December 2019 were retrospectively analyzed. There were 23 males and 5 females, aged (62±5) years (range: 46 to 88 years).The maximum diameter of the tumors was (65.2±10.5) mm (range: 47.3 to 100.5 mm), all of which were subrenal rAAA. The intraoperative EVAR for abdominal aortic aneurysm was successfully performed under the emergency green channel procedure, and this surgery was assisted used the double balloon occlusion technique in aorta of inferior renal and superior renalcombined with intraoperative human fibrin binder injection technique. Observation indexes included: patients with preoperative preparation, operation time, hospitalization days, surgical treatment success rate and the incidence of postoperative complications, and aortic stent form during the follow-up period, the incidence of leakage, branch stents patency rate and infection rates. The preoperative preparation time of 28 patients was (45.5±8.5) minutes (range:20 to 100 minutes). The operation time was (100.0±15.5) minutes (range:85 to 210 minutes), the ICU stay time was (7±2) days(range:1 to 17 days). The length of hospitalization was (13.5±2.5) days(range:5 to 43 days). The success rate of surgical treatment was 92.9% (26/28). Two patients died, 1 case died of postoperative multifocal lacunar cerebral infarction and massive gastrointestinal hemorrhage, and another elderly patient (84 years old) died of massive abdominal fluid due to preoperative abdominal aortic aneurysm rupture, postoperative complicated with significant abdominal compartment syndrome, and secondary multiple organ failure. Balloon occlusion of the upper renal aorta took (13±2)minutes (range:12 to 30 minutes). The intraoperative injection of fibrin adhesive was (14±2) ml(range:6 to 28 ml) in 22 cases. The incidence of major postoperative complications was 57.1% (16/28). Among the 26 patients who survived the surgery, 69.2% (18/26) completed the 3-year follow-up, and the follow-up time was (30±3) months(range:13 to 36 months). During the follow-up, the aortic stent was in good shape without obvious displacement. The incidence of leakage within 6 months after the operation was 10.7% (3/28), and there was no internal leakage in the patients who were followed up for 36 months after the operation. The patency rate of renal artery and iliac artery branch stents was 16/18. The incidence of stent infection was 7.7% (2/26), 1 case occurred at 1 month and another case at 6 months, respectively. All patients recovered after prolonged intensive anti-infection therapy. Under the standard emergency treatment process, the double balloon alternating occlusion technique combined with the intra-aneurysm injection of human fibrin adhesive technique can assist the successful completion of the endovascular repair of rAAA, effectively improve the success rate of treatment for patients, and reduce the incidence of postoperative leakage and serious complications. The mid-term and long-term results of EVAR for rAAA are good, safe and reliable.

摘要

探讨交替双球囊阻断联合瘤腔内注射人纤维蛋白黏合剂在破裂腹主动脉瘤(rAAA)血管腔内修复术中的长期疗效及安全性。回顾性分析2015年1月至2019年12月广西医科大学第四附属医院血管外科收治的28例rAAA患者的临床资料。其中男23例,女5例,年龄(62±5)岁(范围:46至88岁)。肿瘤最大直径为(65.2±10.5)mm(范围:47.3至100.5mm),均为肾下型rAAA。术中在急诊绿色通道下成功实施腹主动脉瘤腔内修复术(EVAR),该手术采用肾上下腹主动脉双球囊阻断技术并结合术中注射人纤维蛋白黏合剂技术。观察指标包括:患者术前准备时间、手术时间、住院天数、手术治疗成功率及术后并发症发生率,以及随访期间主动脉支架形态、内漏发生率、分支支架通畅率及感染率。28例患者术前准备时间为(45.5±8.5)分钟(范围:20至100分钟)。手术时间为(100.0±15.5)分钟(范围:85至210分钟),重症监护病房(ICU)停留时间为(7±2)天(范围:1至17天)。住院时间为(13.5±2.5)天(范围:5至43天)。手术治疗成功率为92.9%(26/28)。2例患者死亡,1例死于术后多灶性腔隙性脑梗死及大量消化道出血,另1例老年患者(84岁)死于术前腹主动脉瘤破裂致大量腹腔积液并术后并发严重腹腔间隔室综合征及继发多器官功能衰竭。肾动脉上球囊阻断时间为(13±2)分钟(范围:12至30分钟)。22例术中注射纤维蛋白黏合剂(14±2)ml(范围:6至28ml)。术后主要并发症发生率为57.1%(16/

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