School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Department of Big Data Science, Korea University-Sejong Campus, Sejong 30019, Republic of Korea.
Food Chem. 2022 Apr 16;374:131630. doi: 10.1016/j.foodchem.2021.131630. Epub 2021 Nov 19.
Finding safe solvents with low viscosities has been in great demand in extraction processes. Herein, R-(-)-carvone, a natural monoterpenoid rich in spearmint, was mixed with naturally occurring fatty acids and terpenes. Most eutectic mixtures presented a wide liquid window in the solid-liquid equilibrium phase diagrams. Carvone mixtures at the ideal eutectic points were characterized for physicochemical properties. Despite varying properties, all the tested solvents were immiscible with water and displayed low viscosity with reasonable biodegradability. Sigma potentials of the mixtures were applied to machine learning algorithms, suggesting carvone mixtures as substitutes for polar protic and dipolar aprotic solvents. Carvone mixtures could be successfully applied to liquid-liquid extraction of a red algae called laver, which is rich in natural hydrophobic and hydrophilic pigments of high value. This study proposes carvone as a new bio-based source of hydrophobic solvents and the eutectic mixtures as biodegradable and tunable solvents to extract hydrophobic compounds.
在提取过程中，寻找安全、低粘度的溶剂一直是人们的强烈需求。在此，我们将富含留兰香的天然单萜 R-(-)-香芹酮与天然存在的脂肪酸和萜烯混合。大多数共晶混合物在固液相平衡相图中呈现出宽的液相窗口。对理想共晶点处的香芹酮混合物的物理化学性质进行了表征。尽管性质各异，但所有测试的溶剂都与水不混溶，且具有低粘度和合理的生物降解性。混合物的表面zeta 电位被应用于机器学习算法，表明香芹酮混合物可替代极性质子和偶极非质子溶剂。香芹酮混合物可成功应用于紫菜（一种富含高价值天然疏水性和亲水性色素的红藻）的液-液萃取。本研究提出香芹酮是一种新型的疏水性生物基溶剂来源，共晶混合物是可生物降解和可调的溶剂，可用于提取疏水性化合物。
